genetic test results

[Sagarcanada]

Hello

CLL fellows and Specialists, Hematologists

I want to share my experience here. We have been fortunate to meet Dr. Christen Chen at the Princes Margaret Cancer Hospital in Toronto. She is very kind and friendly. She has ordered several tests one of them is a FISH test and it is reported as trisomy 12,13q deletion. I want to hear about the results of my wife. I really want to know the following interpretation:

"The signal pattern observed for the chromosome 12 centromere probe showed trisomy 12 in 66.5% of nuclei.

Trisomy 12 is recurrently seen in

multiple lymphoid neoplasms including CLL, mantle cell lymphoma, and follicular lymphoma. In the setting of CLL it is associated with an intermediate prognosis.

The signal pattern observed for the D13S319/D13S25 probe showed a 13q deletion in 50% of nuclei.

The signal patterns observed for the remaining 2 probes (ATM and TP53) were within normal limits

"

I look forward to having comments on it!

Sagar

[AussieNeil Partner Administrator]

Hi Sagar,

As your wife's report reads"In the setting of CLL it (trisomy 12) is associated with an intermediate prognosis". 13q del is best, but only if trisomy 12 isn't detected. ATM and TP53 within normal limits is good; if you have mutated/missing versions of those, then chemoimmunotherapy isn't going to give your wife a good remission, though either will qualify for you for the newer, targeted therapy treatments in Canada.

Great that you've found a kind and friendly specialist for your wife.

Neil

[Sagarcanada in reply to AussieNeil]

Thank you Aussie for your kind response. I wish you happy new year 2023!

As per the result there are two genetic issues 13q deletion and trisomy 12? I am still confused so I think you may answer my question correctly. As per your response 13q deletion is good I still want to know what are positive and negative points associated with it as well as with trisomay 12 ? what specific treatments option available for trisomay 12? As per your experience when the treatment may start as the wbc and Lympocyte are increasing. So I still want to read more comments about the test?

[AussieNeil Partner Administrator in reply to Sagarcanada]

My answer to you is similar to my answer just now to Cave healthunlocked.com/cllsuppo... These markers can shift over time and tracking the rate of progression can give you a firmer indication. Treatments available to your wife nowadays in Canada are likely to provide a reasonable remission. What's more they are likely to improve over time.

Neil

[Sagarcanada]

Thak you Neil

[BobbyFour]

And Princess Margaret is an excellent hospital!