Imbruvica and amlodipine: Hi...Has anyone taken... - CLL Support

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Imbruvica and amlodipine

tlcladygiraffe profile image
5 Replies

Hi...Has anyone taken these 2 meds together and experienced swelling of the legs and ankles?I am dealing with that presently and wanted to know if this has happened to anyone else..please reply asap.

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tlcladygiraffe
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Jm954 profile image
Jm954Administrator

Yes, I did. The swelling got worse as the weeks went by no matter what I did to try to reduce it. It’s a well known side effect of Amlopidine. I changed to Losartan and my legs are fine now and my BP is better controlled too.

tlcladygiraffe profile image
tlcladygiraffe in reply to Jm954

Thanks for the info.

TimHB profile image
TimHB

I take both. I had a little feet swelling early on but it stopped, not sure it was related. I did had severe nighttime leg aches that kept me awake nights. I tried everything including lots of TylenolPM but CBD oil worked wonders. After about 4-5 months, I no longer have the problem and no longer need CBD oil.

Graham2222 profile image
Graham2222

I took both together for two years with no such problem - but that doesn't mean it wouldn't cause problems for some others.

Amlodipine main side effect is lower extremity swelling. My husband had the same issue and I asked that he be switched to Losartan and like myself, once he did, no more swelling. Same with an elderly cousin of mine. So I would attribute to Amlodipine not the combination.

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