I am new to the site...have posted a couple of things this week but didn't introduce myself. I have been on this CLL journey since the age of 37 (diagnosed in 1997); however, I had had swollen lymph glands several years prior. During the past 21 years, I have watched my WCC slowly inch upward with no obvious symptoms; however, a couple of hospitalizations this year (one in January for the flu/pneumonia and one in July for food poisoning dehydration & symptoms that just wouldn't go away), an enlarged spleen, and my overall blood work prompted my oncologist to say it was time to start treatment. I started with Allopurinol (300 mg) on August 18th and then Imbruvica (280 mg) on August 28th. During the first 30 days of treatment, I have experienced a number of side effects, but the tummy distress has resolved and the mouth sores/gum tenderness is getting better. The one that has been the biggest challenge is migrating joint swelling and pain. Prednisone helped tremendously, but my oncologist only wanted me on it a short period of time...once the regimen was over, the swelling and pain returned. I have read on this site where a number of people who experienced this same side effect saw it diminish as treatment progressed...praying that will be the case for me as well!