Atrial Fibrillation, and stroke.

[unun]

AF and Ibrutinib.

Does anyone know of studies about lower doses of Ibrutinib in the U.K. to prevent AF and bleeding

Thanks

[Newdawn Administrator]

Hi unun, do you perhaps mean Atrial fibrillation because auricular relates to the ear?

Regards,

Newdawn

[unun in reply to Newdawn]

Yes. Can you help. Consultant is not willing to reduce drug.

[Newdawn Administrator in reply to unun]

You’ll notice related posts to this question to the right of the screen unun. Others with experience of this issue will be along to advise I’m sure. I have no personal experience of using Ibrutinib however I’d urge you not to reduce the dosage without medical advice.

I’ve edited your post to the correct heading.

Regards,

Newdawn

[unun in reply to Newdawn]

Thanks for your help.

[Cllcanada Top Poster CURE Hero]

Here is the current drug label, see sections, 5.1, 5.4 and dose reduction section 2.3

dailymed.nlm.nih.gov/dailym...

Here is a printable version...

dailymed.nlm.nih.gov/dailym...

I suffered from preexisting A.fib and was on Xarelto while on Imbruvica (ibrutinib), and experience Grade 4 bleeds, only lasted on it 3 months... there was no dose reducing in the early days...

Its a double edge sword... thin the blood to prevent stroke and then the bleeding starts...

They have generalized the dose reductions which I really do not like, it used to be more detailed and specific to each adverse event...

~chris

[unun in reply to Cllcanada]

Thanks Chris for your information.

[umpireman]

I started with 3 capsules of ibrutinib and within four months had to stop because of side effects. My oncologist would not reduce the dosage at that time, said it wouldn't be effective at a lower dose. He later changed his mind and dropped the dose to 1 capsule per day. With the onset of afib and flutter he drop it to 1 capsule every other day. I still experienced afib and he took me off completely. I meet with him tomorrow to discuss a new chemo plan.

[Cgolen99]

I have been taking 1 capsule daily (140mg) due to severe joint pain and swelling on higher doses.. still dealing with it but now manageable with prednisone.. 140 mg is effective thus far..

[TimHB]

I've been on ibrutinib with obinutuzumab for six months now and thought I was doing great. After first spiking, my numbers dropped quickly into the normal range and I was feeling good. Then the afib happened. I've been hospitalized 3 days so far with no end in sight with an irregular heart rate as high as 170. I'd had a few days of rapid heart rate, dizziness, fatigue and agitation before I went to the emergency room. No answers yet.