Any opinions on these results before I see the specialist next week?

[hhk50]

I had a bone marrow biopsy done and the flow cytometry results were posted on the hospital website today. I don't see my doctor until next week so I thought that I would post the results here to get some opinions before I see him. I know that the CD38 positive at 41% is not good. Anything else I should make sure to question him on?

Final Diagnosis:

Bone marrow, flow cytometry:

Phenotypic study reveals CD5(+) B cell neoplasm, with immunophenotype

typical of B-cell CLL.

Interpretation:

Lymphocytes

comprise 94% of total events. The majority of lymphocytes are

B cells that are positive for CD5, CD19, dim CD20, CD23, CD45, CD200 and

monoclonal lambda (dim), and negative for FMC7.

These results are diagnostic of a CD5(+) B cell leukemia/lymphoma, with

the immunophenotype typical of B-cell CLL. This phenotype can be observed

and other B cell neoplasm subtypes, therefore morphologic and cytogenetic

correlation recommended.

B Cell Associated Markers (% Positive Cells):

CD19 = 96; CD20 = 88; CD23 = 64;Kappa = 0; Lambda = 84; Kappa:Lambda ratio

= 0.0

T Cell Associated Markers (% Positive Cells):

CD2 = 3; CD3 = 3; CD4 = 2; CD5 = 83; CD7 = 2; CD8 = 1;CD4:CD8 ratio = 2.0

Miscellaneous Markers (% Positive Cells):

CD1d = 1; CD10 = 0; CD34 = 0; CD38 = 41; CD45 = 100; CD56 = 0; FMC7 = 2;

CD200 = 96

Cell Viability (%): n/a

Number of Cells Analyzed: 10,000

Total Number of Markers: 24

Summary of Marker Combinations:

Kappa/Lambda/5/10/19/45/38/20; FMC7/23/200/34/1d/45/5/19;

2/7/5/3/4/45/56/8

[Cllcanada Top Poster CURE Hero]

CD38 at 41% says unmutated... I would ask to have a direct IGHV test done. CD38 surrogate to IGHV has been 'OK' for 12 years or so clinically, but now we need the real thing...

~chris

[hhk50 in reply to Cllcanada]

Thanks, Chris. I also had a FISH performed with only the 13q showing an abnormal pattern but at a low level which got a thumbs up from the hematologist. At that time, he mentioned that he was still awaiting the "Next Gen Sequencing" test. Would that be the one that would show the IGHV status?