I had a bone marrow biopsy done and the flow cytometry results were posted on the hospital website today. I don't see my doctor until next week so I thought that I would post the results here to get some opinions before I see him. I know that the CD38 positive at 41% is not good. Anything else I should make sure to question him on?
Final Diagnosis:
Bone marrow, flow cytometry:
Phenotypic study reveals CD5(+) B cell neoplasm, with immunophenotype
typical of B-cell CLL.
Interpretation:
Lymphocytes
comprise 94% of total events. The majority of lymphocytes are
B cells that are positive for CD5, CD19, dim CD20, CD23, CD45, CD200 and
monoclonal lambda (dim), and negative for FMC7.
These results are diagnostic of a CD5(+) B cell leukemia/lymphoma, with
the immunophenotype typical of B-cell CLL. This phenotype can be observed
and other B cell neoplasm subtypes, therefore morphologic and cytogenetic
correlation recommended.
B Cell Associated Markers (% Positive Cells):
CD19 = 96; CD20 = 88; CD23 = 64;Kappa = 0; Lambda = 84; Kappa:Lambda ratio
= 0.0
T Cell Associated Markers (% Positive Cells):
CD2 = 3; CD3 = 3; CD4 = 2; CD5 = 83; CD7 = 2; CD8 = 1;CD4:CD8 ratio = 2.0
Miscellaneous Markers (% Positive Cells):
CD1d = 1; CD10 = 0; CD34 = 0; CD38 = 41; CD45 = 100; CD56 = 0; FMC7 = 2;
CD200 = 96
Cell Viability (%): n/a
Number of Cells Analyzed: 10,000
Total Number of Markers: 24
Summary of Marker Combinations:
Kappa/Lambda/5/10/19/45/38/20; FMC7/23/200/34/1d/45/5/19;
2/7/5/3/4/45/56/8