My husband Murray is in a very precarious state right now and I would sure appreciate your input. Just to summarize - he is 58, diagnosed 3 1/2 years ago but with symptoms for many years before that, 13q, 11q & trisomy 12, relapsed quickly after FCR, on ibrutinib for 9 months, scheduled for stem cell transplant in January. He has had to reduce his ibrutinib due to neuropathy & now went off it because his platelets are down to 6 (normal being 150 to 400). He is having platelets every few days and really doesn’t feel that bad but this is scary! His medical team seems really puzzled. Any ideas? Anyone else have experience with this? I asked about Richter’s but they say no because his spleen seems good and he doesn’t have some of the other symptoms.