Venetoclax Plus Rituximab Is Superior to Bendamustine Plus Rituximab (Murano Study)

[Korstiaan]

Today on the ASH 2017 Meeting, the results of the Murano Study were published:

ash.confex.com/ash/2017/web...

I was one of the 389 participants in this trial and off course I am very happy with the conclusion, demonstrating that treatment with VR resulted in outcomes superior to that of BR for pts with R/R CLL.

Best wishes to all of you, Korstiaan

[skykomish]

Wow. The V+R has an impressive Kaplan-Meier curve, especially for R/R patients.

[Justasheet1]

Korstiaan,

Awesome news!!!!!

Jeff

[Anja-Jantina]

Hi Korstiaan, i am also Dutch (i have SLL unmutated) but living in Germany. I wonder how you are today?

It is now about 9 months you finished Venetoclax? Did the result of the treatment last? Are you using medication today? Are you still feeling fine?

[Korstiaan in reply to Anja-Jantina]

Hi Anja-Jantina, I finished Venetoclax somewhere in September / October 2017. So that's almost a year ago. I visited my CLL specialist last August and all bloodcounts were very good. That was after a three weeks holiday in the USA.

Just (two weeks) before my holiday I had some problems with my gall bladder (resulting in being removed), but that had nothing to do with the CLL. Since I stopped Venetoclax I am not using any medication.

And I am very happy to feel fine. I experience no restrictions in my daily life (working, sports, etc).

I hope you feel fine as well?

Best regards, Korstiaan

[Anja-Jantina in reply to Korstiaan]

Good to hear that you are doong fine. Unfortenately i am not doing great ( though not doing terrible eitger). I was diagnosed in jan 2017 with sll unmutated, more aggressive than usual stage C. Later they returned it to stage B. I refused chemo, as i read that in my case it would be of no use. Later the Cll specialist confirmed this. I was offered ibrutinib which i delayed because you cannot stop with that medication without the disease comming back more aggressively as before. The cll specialist agreed with this too. I tried natural treatments. I am going to a hospital in Germany for 4 times a year fir 10 days. Then i have hyperthermia treatments, last time with liposomales quercetin and vit c infusions. That was a good combo, my blood counts were almost normal after that. Unfortuneraly i have to be very consequent with my diet, otherwise the disease detoriates fairly fast again. And sometimes i just fo not want to think about diseases and just eat what is in front if me. But i have a lot of pain at the moment. Had two mri’s to see if their is neurological involvement and am now on prednison to calm down lymphnodes that are so painful.

Venetoclax sounds not too bad for me. Maybe i ask to participate in a trial in Germany, if the pain does not go away.