Ibrutinib, SNS-062, and CAR-NK

[bkoffman]

Hi,

It’s been a bit crazy, but I wanted to share that I have posted on our nonprofit’s website cllsociety.org an interview from ASH about the particularities of ibrutinib as compared to other BTK inhibitors from the perspective of a Janssen executive, news about a new trial of an experimental BTK inhibitor that doesn’t bind to C481 and is therefore helpful to many who become resistant to ibrutinib due mutations in that binding site, and finally some promising information on CAR-NK cells, a possible step towards a scalable "off the shelf" cellular therapy.

It seems in CLL, every week brings news and that is a good thing. In contrast and to give some perspective, it has been more than a decade since there has been a new drug to treat MDS.

We post new material almost every week. It’s a lot of work, but there is always something new to learn. Please consider signing up for our weekly alert. It helps us. Whether you do or not, as always all our material is free and we never ask you to sign in to see anything on the website. In fact, all our material is available to download.

Stay strong.

We are all in this together.

Brian

[Jm954 Administrator]

Website looks good, I've signed up. Thank you and thanks for the interesting and informative posts!

[CLLCalifornia-USA]

Thanks, Brian. I've signed up. Looks like useful information. Sally (USA)

[Hoffy]

Brian, Thanks as always.

Sort of related to this I met a person last week who has had CML for 12 years. She first tried Geevec but it did not work for her. Something to do with the binding. I am not an expert. She was looking at a Bone Marrow Transplant but went on a clinical trial for a new form of Geevec with a different binding mechanism and she did great!!! It is called dasatinib (Sprycel) I think . She was on the trial for another few year and now continues to take the drug off trial for many years( 12 years total). She has a baby in the mean while and is living a normal life now in her mid 40's. Hopefully this is predictive for the path of CLL as well!!

Be Well,

Hoffy