Encouraging results from son of Ibrut... - CLL Support Assoc...

CLL Support Association
13,535 members21,242 posts

Encouraging results from son of Ibrutinib studies (Acalabrutinib/Calquence)

AdrianUK
AdrianUK
19 Replies

In case you need any more persuasion that we are in exiting times for the future of CLL, read this article about the exciting results of a drug which all being well may one day replace ibrutinib. Not every promising drug gets all the way through. But when you have a drug with a similar target but hopefully fewer side effects the likelihood of success improves.

cancer.osu.edu/news-and-med...

Title changed so information on Acalabrutinib/Calquence can be found via Search - Admin

19 Replies
oldestnewest
Justasheet1

It’s already approved for Mantle cell cancer. I’m hoping we’re next this year.

I’m guessing if you’re intolerant to Ibrutinib it will be the go to drug.

4 likes
Reply
Ladydi49

Do you know the name of the drug?

Reply
Cllcanada
CllcanadaTop Poster CURE Hero
in reply to Ladydi49

Calquence (acalabrutinib) should be available in the U.S. fall 2018, but no sure bets.

~chris

7 likes
Reply
DaleFL
DaleFL
in reply to Cllcanada

For CLL?

Reply
larrymarion
larrymarion
in reply to DaleFL

while not officially approved for CLL by the FDA, it is being prescribed by many docs for patients with R/R CLL who are having problems with ibrutinib. And some insurance companies are approving the Rx for CLL, too.

1 like
Reply
bhayes84
bhayes84
in reply to Cllcanada

Why isn't it available now Chris?

Reply
Cllcanada
CllcanadaTop Poster CURE Hero
in reply to bhayes84

Its up to the drug company to start the process for approval, likely they are waiting for more data. Since its already been reviewed by the FDA for safety concerns in the MCL approval, it's easier and faster to get a second indication, CLL second line approved.

I don't know were things stand at the moment, Astrazeneca hasn't given any indications either...

~chris

1 like
Reply

Ibrutinib works well for me so far, but love having another drug on the shelf just in case. Thanks, Sally

2 likes
Reply
Kwenda

Good news obviously, less side effects such as AF..

BUT will it be affordable, and can NICE agree a price in the UK that the NHS will also agree to.???

Dick

2 likes
Reply
Justasheet1
Justasheet1
in reply to Kwenda

Pricing should be in line with Ibrutinib.

Reply
Cllcanada
CllcanadaTop Poster CURE Hero
in reply to Justasheet1

Second in class drugs have a rough time, some like ofatumumab fail...simply due to cost. I hope Calquence (acalabrutinib) comes to market at about $90,000 annually, compared to Imbruvica (ibrutinib) at $148,000 it will be a bargain.. win over funders and insurance companies, get it in broad use, then worry about price.

~chris

6 likes
Reply
AdrianUK
AdrianUK
in reply to Cllcanada

Getting the pricing strategy right will be crucial for them. What’s the price for their current indication?

Reply
Cllcanada
CllcanadaTop Poster CURE Hero
in reply to AdrianUK

100mg BID, for MCL

The wholesale acquisition cost for Calquence is $14,260 per month, certainly comparable to Imbruvica (ibrutinib), but who knows...

I have no idea of the market size... drug pricing in the U.S. is largely smoke and mirrors.

professionals.optumrx.com/c...

Also see

reference.medscape.com/drug...

~chris

3 likes
Reply
Ladydi49

I hope so. I can't take Ibrutinib due to mild cardiac issues so my choices are Bendamustine with Rituxan or Gazyva. Sadly, I think Ibrutinib would work for me😕

3 likes
Reply
DaleFL
DaleFL
in reply to Ladydi49

Hang in there. It will come.

Reply
SMS-not-cll

You did it again, AdianUK! Thanks for sending this link.

Our CLL treatments keep improving to give us a brighter future.

Wishing good days and good health to all.

SMS

Reply
mgh348

I have been on acalabrutinib for 18 months very successfully with few side effects. Truly has been a blessing.

7 likes
Reply
Corkyrissa
Corkyrissa
in reply to mgh348

Does your insurance pay for Acalabrutinib or are u on clinical trial? What are the side effects.? I had been on ibrutinib for 19 months and dr stopped it because I’m being monitored for Afib now. Ty

Reply
mgh348
mgh348
in reply to Corkyrissa

I'm on a clinical trial at Mayo in Jacksonville. I had headaches and some mild diarrhea for a few weeks. An inflamed finger joint and achy knees for a few months. Hot flashes and blood pressure spikes in the middle of the night, but not sure what was causing them. Now on BP meds and they have stopped.

Reply

You may also like...