Hello. I'm enrolled in a study at OHSU that is evaluating tirabrutinib (ONO/gs-4059) in combination with various other treatments. My arm of the study is for tirabrutinib as a single agent drug and I'm now completing week 4 taking a single 80mg tablet daily. So far, only very minor headache and lower back pain due to muscle tightness.
I was diagnosed in 2009 with deletion 13, high CD 38 and intermediate Zap70. Discovered early, I think, due to regular blood testing while in treatment for rheumatoid arthritis.
Treated with obinutuzumab in 2014-2015 with very good results, reaching CR and MRD negative. As a tremendous plus, my RA has also gone into remission!
Relapsed two years following end of the obinutuzumab treatments.
Have great hopes for tirabrutinib, which I've heard described as a version 2 of ibrutinib, both being BTK inhibitors. I'll try to keep you all apprised of my progress and experience with this treatment.