Can Yogurt Fight Antibiotic Resistance? Lactobacillus isolate inhibits multi-drug resistant bacteria

Can Yogurt Fight Antibiotic Resistance? Lactobacillus isolate inhibits multi-drug resistant bacteria

Researchers here may have found an unlikely ally in their fight against antibiotic-resistant pathogens -- commercial yogurt



The isolate was identified as Lactobacillus parafarranginis KU495926 and it inhibited 14 multi-drug resistant and extended spectrum beta-lactamase bacteria, which are known for breaking down antibiotics.


These results suggested that Lactobacillus parafarranginis KU495926 may be a novel strain that could be worth exploiting for the development of potential therapies in the fight against antibiotic resistance, the authors said.

"Considering the current upsurge of antibiotic resistance in hospitals, especially among the gram-negative bacteria, and the exigent need to find viable alternatives, findings from the study may hold promise for possible therapeutic application," said Allen-McFarlane in a statement.

Note that it was an isolate that was found to inhibit multi-drug resistant bacteria, so I expect eating yogurt is unlikely to help due to the low concentration of this lactobacillus.


10 Replies

  • Interesting ...

    Nothing alive in most commercial yogurts... hence the 30 day cooler life... Buy yogurt starter and make your own... pretty easy

    Most yogurts are heat treated after the yogurt is made, killing the bacteria.

    If it says on the label 'Live and Active Culture' then it has not been heat treated.


  • Good points to which I should add that if you are neutropenic, be very careful about making your own (eat it within 24 hours) and perhaps eating yogurts with probiotics may not be wise.

  • Here is previous post... on probiotics and sepsis..

  • I am sold on yogurt for working against diarrhea while taking antibiotics. The caution there is to take the pills 2 hours before or after eating yogurt. It works. The timing is important because the calcium in the yogurt interferes with the antibiotic if taken at same time.

    Also, the caution re: live and active culture is important, like Chris said. And I agree with Neils statement about the do-it yourself route.

  • The specific species of bacteria and fungi are very important. I asked the Google Bird about lactobacillus parafarranginis, and found only one reference other than that recent paper:

    I think that the KU495926 actually defines an accession number - a variant of the species that someone has sequenced and cataloged.

    It is apparently not present in most commercial bovine milk yogurt. Based on the Google Books result above, it has been found in a Mongolian drink based on equine milk, along with other species of microbes plus alcohol.

    PubMed had more references to lactobacillus parafarranginis, including this one regarding fementation products of spanish olives:

    Note that they also found Vibrio vulnificus in fermented olive, which is a serious pathogen. It's possible that it entered the product through a seawater brine. Vibrio tolerates salt well. It leads to septicemia even in healthy people.

    Fermented foods are the latest "health" fad, and do not have adequate research to support benefits from specific foods, in my opinion. This paper is the result of some of that needed research that has teased out 1 species from the many millions possible, and the possibly dozens to hundreds of species present in the food.

    The theory is that fermented foods promote diversity of species in the gut, and that tribal hunter gatherers have more diversity than modern societies. Hunter gatherers are thought to be more "natural." But I argue that hunter gatherers also have very low life expectancy (<50 years) due to infant and maternal mortality, as well as injuries among adult males. It's not clear how much of this is due to digestive disorders or infections.

    So I'm thinking I'll wait on this new species to become extracted and turned into a product, and continue with my daily Chobani low fat yogurt, which has live S.Thermophilus and L. Bulgaricus at the factory which hopefully survives the trip home, They are well studied and generally recognized as safe.

  • Let food be thy medicine -

  • I was diagnosed with C - difficile about 11 years ago, ( age 51 ) way before I had CLL. ( cultures were done before and after treatment ). I did not have antibiotics for years beforehand, or a hospital stay where I may have caught it. After treatment with metronidazole, it was recommended that I start taking the probiotic saccharomyces boulardii. I also take other probiotics as I eat very little goats milk yogourt.

    I am not sure what would be recommended if I became neutropenic, - lowest count 1.3 so far, but I certainly would not want to take the chance of having C - difficile again. I lost 25lbs which I have kept off ( do not recommend this as a weight loss program ) and took months to recover physically and normal gut function. It is a very serious disease and can understand why elderly patients die from it.

    If anyone has any scientific knowledge regarding how a patient like myself would be treated, I would be most grateful to hear from them.

    Sandy Beaches

  • There is lots of information of fecal transplant and the new fecal pills... University of Calgary

    has run clinical trials as has University of Toronto. Both have had a very high cure rate for chronic C.diff over 90% in older patients.

    University of Guelph has a synthetic pooh pill... Repoopulate

    I must have 5-6 posts here on this subject... try a search.

    Canada is on the cutting edge of this 🚽🚽🚽

    An open source project internationally, because fecal micro biomes vary.. like money in the poop bank.


  • I have read about fecal transplants, but the synthetic pills would be much more appealing if I ever need them. I am wondering if antibiotics would wipe out the good flora from the synthetic Repoopulate and if one would have to repeat the treatment with each round of antibiotic or just keep taking the pills through antibiotic treatment. Have to do some reading on this.

    Thanks for the links, Chris, and let's hope no one has to deal with a C - difficile infection.

    Sandy Beaches.

  • You've done well not having a recurrence of C-difficile after your CLL diagnosis, so I hope that's reassuring. Understanding how our gut biota is influenced by our diet and how that affects our health is currently the focus of plenty of new research, so keep across the latest developments. Current research is highlighting the importance of eating widely of minimally processed foods to increase the varieties of good gut bacteria to improve our overall health and reduce the risk of gut infections.


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