This week, I am sharing some basic science that reminds us that nothing about CLL is simple and that drugs nearly always have unintended and often unexpected consequences.
I explain the importance of a recent article from Nature: P13Kδ (phosphatidylinositol 3-kinase δ) blockade increases genomic instability in B cells where we learn how the tremendous therapeutic benefit of a drug may also be linked to potential concerns. You can read my summary and link to the abstract from Nature here: cllsociety.org/2017/03/p13-...
It’s a tough article to get through, but it has many possible implications.
We are all in this together.