Hi,
I have been deciding about when to do treatment but now I have had a sudden jump in ALT and AST indicating liver issues. I have lots of B cll symptoms but no symptoms of infection. Are there drugs that do not compromise the liver for cll or is this latest issue going to decide for me not to do chemo. My internist is waiting to hear from my oncologist but I was just curious if anyone here could offer some wisdom. Thanks for any thoughts.
Jill
Jill,
Are you taking anything new? Supplements, Tylenol on a regular basis, NSAID's?
Anything to explain the sudden jump?
Liver function tests are not a driver for treatment.
Jeff
Not taking anything new. I was just wondering whether some of the cll treatments were less toxic to the liver.
The only one I know of that can cause elevated liver enzymes is idelalisib for 2nd line treatment.
Thanks
Idelalisib can also cause elevated AST and ALT levels when used as a frontline treatment-at least it did for me
John
Idelalisib has been removed from frontline use... due too deaths in clinical trials last summer...
Certainly hepatotoxicity has seen in first line use...
~chris
when treatment time comes, there is a drug, called ursodiol here, that can help protect the liver when under treatment with certain drugs. as always it's something you'd bring up with your doctors. my husband has been on it for some time and the doctor said it can also help with graft-vs-host attacks on the liver, post transplant.
wishing you all the best --
Thank you so much. I am getting some tests to rule out non cll stuff so we shall see. I appreciate all the advice. Hugs my friends 💕
High Alkaline Phosphatase 
CLL; when is treatment?
Abnormally high liver enzymes
Lymph nodes that are multiplying 
When to treat?
