Metformin is the most widely used drug to treat type 2 diabetes globally.
More snippets from the article by Merlin Thomas, Adjunct Professor of Preventive Medicine, Baker IDI Heart & Diabetes Institute, which I hope will be at least of interest for those with a diabetes II co-morbidity with their CLL, : theconversation.com/weekly-...
'Metformin was originally developed from natural compounds found in the plant Galega officinalis, known as French lilac or goat’s rue.
Synthetic biguanides were developed in the 1920s in Germany, but their use was limited due to side effects. During the 1940s, however, French physician Jean Sterne examined a new biguanide called dimethylbiguanide or metformin. At the time, it was being studied for the treatment of influenza, but Sterne recognised it had glucose-lowering properties. He proposed calling it glucophage, meaning glucose eater, a name with which it is still commercially associated today.
Metformin has been used to treat diabetes since the late 1950s. It is now on the World Health Organisation’s List of Essential Medicines needed for a basic health care system.
Metformin is associated with a rare but life-threatening condition known as lactic acidosis, where the body builds up too much lactic acid. This can be caused by factors such as heart, liver or kidney failure. There is still controversy over whether metformin is the cause of lactic acidosis or whether it exacerbates the condition.
Metformin competes for clearance by the kidneys with drugs including digoxin (for heart rhythm problems) trimethoprim and vancomycin (antibiotics), ranitidine and cimetidine (for heartburn), nifedipine and furosemide (for blood pressure) which all have the potential to modestly increase metformin levels.
Some clinical trials have shown that metformin is at least as effective as diet and exercise for preventing diabetes in those at high risk of developing it.'
Photo: Pink fairy orchids recently found in the scrub. These native orchids have had an exceptional year thanks to our wetter than average winter and spring.