'Smoking scars DNA in clear patterns, researchers reported Tuesday. Most of the damage fades over time, they found — but not all of it.
Their study of 16,000 people found that while most of the disease-causing genetic footprints left by smoking fade after five years if people quit, some appear to stay there forever.
The marks are made in a process called methylation, which is an alteration of DNA that can inactivate a gene or change how it functions -- often causing cancer and other diseases.
"Our study has found compelling evidence that smoking has a long-lasting impact on our molecular machinery, an impact that can last more than 30 years," said Roby Joehanes of Hebrew SeniorLife and Harvard Medical School.
...smoking-related changes in 19 genes, including the TIAM2 gene linked to lymphoma, lasted 30 years, the team found.'
From NBC News coverage of Epigenetic Signatures of Cigarette Smoking; American Heart Association, Cardiovascular Genetics: circgenetics.ahajournals.or...
NBC News coverage: nbcnews.com/health/health-n...
The mentioned TIAM2 gene linked to lymphoma is the T-Cell Lymphoma Invasion And Metastasis 2 gene.
While CLL doesn't get a specific mention, we have a higher risk of secondary cancers, with skin and lung cancers most common. One study found that '85% of the lung cancer patients were smokers. The lung cancer was at least twice as common in men compared with its incidence in women, and the diagnosis was made approximately 8 years after the diagnosis of CLL. Along with a poor performance status, the presence of CLL was found to be a limiting factor for delivery of treatment for the lung cancer.'
Irrespective of the risk of lung cancer, anaemia is a common complication as CLL progresses and fatigue can be a problem at any stage, so why make it harder for your body to have access to life giving oxygen?
Photo: Not smoke, snow, frost or hail, but gossamer spider webs draping the countryside