Many thanks to all who responded to my query re Ibrutinib and Ibuprofen. In the end consultant said not a good idea. Im any case I am still suffering severe muscle pains and have dropped down to only 1/3 dose. If pains continue will have to stop Ibrutinib. Very disappointing. My blood results have improved greatly since start of FLAIR trail in November 2015, from peak of over 300 now down to 59 WBC. If I have to stop what are my options. FCR I guess....unless I qualify for another trial...Feeling very fed up.