Not CLL related, but more along the lines of where familiarity may result in us overlooking something we've long considered safe to take and which may longer be the case when we start taking other drugs for comorbidities that become more likely as we age... Paulina Stehlik, Associate lecturer, University of Sydney explains how Ibruprofen works and situations where alternative pain killers may be more appropriate:
Note particularly in the side effects section:
"Ibuprofen and other NSAIDs can cause gastric upset if taken on an empty stomach, so should always be taken with food. This is why paracetamol is usually recommended in the first instance for aches, pains and fevers. It has fewer gastric side effects and in most cases is just as effective as NSAIDs.
While reducing prostaglandin production results in ibuprofen’s therapeutic effects, prolonged reduction in prostaglandin production due to chronic NSAID use decreases the secretion of protective substances in the gut, changes platelet activity and decreases filtration rate and blood flow in the kidneys.
This can result in gastric ulcers and bleeds, increased blood pressure, decreased kidney function and renal failure, heart failure and cardiovascular events such as heart attacks and stroke. This is why all NSAIDs are recommended for short-term use only unless under the supervision of a medical practitioner.
You must see a doctor immediately if after taking ibuprofen you experience swollen ankles, difficulty breathing, chest pain, black or red stools, or dark, coffee-coloured vomit."
The Interactions section is also worth a read.