Hello! My brother has had CLL for a long time, years. About a year ago, the 'watch and wait' period was over and he needed to begin treatment. First, was chemo, and it wasn't effective. Then they went the Ibrutinib route and it seemed to work like a charm, white count went down, spleen returned to normal size and was feeling okay, with few side effects. Then came the back pain, the horrible back pain. Turns out there are lesions on his spine and the jury is still out as to what it is - PET scan is scheduled to figure it out - another cancer (possibly prostate) or some other infection. Does anyone have any experience with this? is it normal to develop another cancer along with the CLL? I assume it might be. Any positive stories of survival? or, is this a really really bad sign. I just want to know what I need to prepare for.