From Japan. I am stage A of CLL, p13 deleted. CD20 positive (not so strong expression). My situation is watch and wait. In Japan, we have only 2000? CLL patients, so hematologist's experience to treat CLL patients is a little. My hematologist told me that let's try fludarabin (F) mono therapy as a first line therapy, when the time will come to need treatment. I know that recent standard treatment is fludarabin+cyclophosphamide+rituximab (FCR). Before I will discuss with my hematologist, I want to ask your opinions. Anyone have experience with only fludarabin mono therapy?
I want to ask another questions on RCR treatment. I have heard that rituxian(rituximub) may cause rapid and quite serious allergic response. therefore, I think that patients are treated in hospital under doctor's observation (not your home!) at the first round treatment of FCR. Also I have found posts in this site that first rituximab was infused 100 mg? in a first day and if no problem, next day 500 mg? was infused. Basically Rituximab infusion divide into twice ? In japan, rituximab infusion is performed once a day. Sometimes serious allergic reaction occurs.
I have heard that only fludarabin caused serious side effects such as fever (around 39~40C) at the first treatment. I guess that it need to be in the hospital under doctor's observation at the first time of treatment even fludarabin mono therapy.
I appreciate if you might post your experience.