Flow symmetry

now I'm even more confused & I don't see the Hemayolgist until mid-Aug. I went online & found out some test results from the new Hematologist who redid everything (blood work):

1) beta 2 is high

2) "CD38 expression is dim heterogeneous.

ABNORMAL CELL IMMUNOPHENOTYPE:

(+) CD5, CD19, dim CD20, CD23, dim heterogeneous CD38, dim kappa

(-) CD10, FMC7, lambda, other T-cell markers "

I've never heard the words dim or lambda or heterogeneous or fmc7 used in my results before....

Can anyone explain what any of this means besides a confirmation that I do indeed have CLL?

Thank you!

2 Replies

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  • Dim or bright refer to fluorescent staining intensity of a sample when compared against a standard. Generally, CD20 in CLL is 'dim' but in trisomy 12 patients it is occasionally found to be 'bright' ... in effect, they have more CD20.

    Complex but well explained here

    wiki.clinicalflow.com/Cases...

    CD20 and FCM7 tend to go hand in glove, FCM7 is usually only found on cells with 'bright' CD20... FCM7 is used on occasion to separate CLL diagnosis from other B cell cancers...

    ajcp.ascpjournals.org/conte...

    Beta 2 microglobulin, is a prognostic indicator in CLL, but it must be interpreted by a pathologist where other factors like kidney function, age etc. plays a role...

    bloodjournal.org/content/10...

    hematologylibrary.org/site/...

  • Thank you for replying- it helped a little unfortunately it still is a foreign langauge to me...I guess mostly I am going to have to wait until I see the Dr. in mid-Aug. I received a ton of results back but he didn't say anything about the results...

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