NOTCH1 new risk marker?

[Cllcanada]

NOTCH1 gene encodes a member of the Notch family. Both NOTCH1 and NOTCH2 are constitutively activated in B-cell CLL but not expressed in normal B cells and may be involved in survival and resistance to apoptosis in CLL

This study concluded that ' both NOTCH1 and TP53 mutations seem to be independent predictive markers for worse outcome in CLL-patients and this study emphasizes the contention that NOTCH1 mutations is a novel risk marker.'

Full paper from Sweden

biomedcentral.com/content/p...

Also see

ncbi.nlm.nih.gov/pmc/articl...