Cystic Fibrosis - Functional Bile Duct Cells Generated From Stem Cells

[Richard-Allen]

A condition that is rarely mentioned here is Cystic Fibrosis. This may be due to fact that Cystic Fibrosis is considered to be a lung condition, but CF can cause the blockage of small ducts in the liver leading to CF-related liver disease.

Liver disease in people with CF can be related to problems with the drainage of bile out of the liver via the bile ducts and gallbladder, or to scarring in the liver, which is known as fibrosis and cirrhosis: cysticfibrosis.org.uk/what-...

However, a report published today by researchers at the University of Toronto and its partner hospitals has discovered a way to generate functional cells from stem cells. This technic offers fantastic opportunities for people with CF and possibly those who suffer from PBC (Primary biliary cirrhosis) and PSC (primary sclerosing cholangitis). I have known several people who have suffered from PBC needing more than one liver transplant during their lifetime.

Indeed, I met a nice young lady from Belfast back in 2019, who had endured three liver transplants, she was in her early twenties. She had two of these transplants carried out when she was a child. We tend to forget on here that children also suffer from liver-related conditions too.

This finding offers a course of treatment that could hopefully prevent the need for a liver transplant by reversing the damage caused to the bile ducts and in turn preventing damage to the liver.

For those who may be interested, this article can be found at: technologynetworks.com/cell...

This may still be early days but from little acorns grow might oaks

Richard.

[Hidden]

That's a wonderful find Richard. And it offers a double bonus. For every person that we keep from or take from the transplant list, it gives an opportunity to save another person. At present there appears to be some promising developments in liver disease.

Dave

[Hidden]

This can’t come soon enough for those with CF. Any new treatment that can significantly impact upon the physical consequences of the disease is much needed.

For those who are often so young, the overwhelming burden and mental health consequences of having CF, can also be catastrophic. As well as saving lives, this may give a sense of there being at least one aspect that can be controlled a little better.

Along with MND, CF has to be one of the most cruel diseases. Thanks for sharing the information.

[Tia2021]

Thank you for sharing this its very interesting, ☺️👍

[Hidden]

Thank you very much for sharing Richard.

Here is the Trust information on Cystic Fibrosis related liver disease;

britishlivertrust.org.uk/in...

[gillrich]

Thank you for his article