My mother (age 52) is a patient of Breast Cancer- T2N0M0 [IDC - infiltrating ductal carcinoma (NOS) grade III, MBR score (8/9)].
Her tumor was tested (post surgery) for ER, PR and Her2-neu. Second opinion was also taken on blocks and slides. But to our surprise, both reports are different.
The first report is of MAX hospital Delhi and the second report is from Oncquest Laboratories, Delhi.
Report 1: IHC performed
ER – Negative with Allred Score 0/8
PR- Negative with Allred Score 0/8
Her2neu- Positive with Score 3+
P53 – about 35% to 40% (nuclear positivity)
Ki67- about 25% to 28% (proliferation index)
Report 2: IHC performed
ER- Positive with parameters: [ % cells= 15 % and intensity= moderate]
PR- Negative with parameters: [ % cells= 00 % and intensity= NA]
Her2neu – Positive ( FISH positive)
P53- Positive weak to moderate in 10% cells.
Ki67- about 60%
The first report says that ER is negative while the second report says that ER is positive. What should be done in this case - Should my mother take hormonal therapy after her chemotherapy and radiation therapy?
Also we can see differences in Ki67 and p53. How to attribute to these differences ?
Should I get a third opinion? and from where ? Please suggest any place from where I can get a bench mark report.
I have heard about whole genomic analysis (molecular testing) for breast cancer. Should we get it done ? What is it actually ? Will I get confirmed results from this test? Where should I send the blocks and slides for genomic/molecular testing ?