Epleronone side effects?

[Cliff_G]

A penny may have dropped.

I have been on Epleronone (mainly for BP) for about 4 years, after a challenging aortic dissection repair. I recently had an ablation for atrial flutter and whilst waiting was put on Diltiazem to slow my rate. This dropped my BP too low so the GP agreed I should come off the Epleronone, which corrected the BP, and I was off it for about 3 months. After my semi-successful ablation I restarted Epleronone (no longer needing Diltiazem for its original purpose).

Whilst (in my complex situation) it's hard to tell what's causing my lack of energy, I have recently noticed a regular daily pattern. I'm OK when I wake, then during breakfast (when I take the Epleronone) I feel my energy wane and by the end of the morning I am absolutely wiped out. This carries on through lunch and early afternoon, but by late afternoon the wipe-out feeling recedes and I can even get out and do some gentle gardening. So I am wondering if the Epleronone is the cause. Its half life is 4 to 6 hours and though film coated is not slow release.

Obviously I shall try a bit of a controlled trial off it to test this theory, but I'm just wondering, therefore, whether anyone else has had experiences they can pin down to Epleronone? I know my GP is a little wary of it, having had to take someone off it due to it causing sleep problems.

Thanks in advance

C.

[Happyrosie]

and if you don’t get any useful responses here, have a word with one of the pharmacists that your doctor’s group of surgeries employs, or your dispensing pharmacist. They’d be the experts advising your own general practitioner

[Buddy00]

I am taking a cocktail of meds , one being Eplerenone. The tiredness and shear exhaustion that I feel at times I have associated with the beta blocker bisoprolol that I take. I only say that as I was originally taking spiroloctane ( excuse spelling ) but had to swap to Eplerenone due to side effects and still felt tired and exhausted.

[MountainGoat52]

I was on Eplerenone for 15 months and had no issues with tiredness, but it did affect me physically on my chest, a well known issue for some males. I couldn't wait to get off the medication and it took a few years to get back to normal. The only medication that made me tired was the beta blocker Bisoprolol.

[Lesmis85]

I take Epleronone and one other BP med and had similar side effects to you, Cliff_G. I now take them at night and it has helped. I feel better in myself but still get a degree of exhaustion.

[Cliff_G in reply to Lesmis85]

Thanks. I take mine in the morning as they are diuretic, so didn't want to be up in the night (more than I already am!). Will see what the trial off them does, then maybe try at night.