Enteric-coated Aspirin, anyone?

[STEMI_Dave]

My GP changed my prescription from dispersible to Enteric-coated Gastro-resistant Aspirin to try to deal with morning queasiness, but there's no instructions from him or the dispensing pharmacy on the best time to take these. As they are absorbed differently, has anyone got any experiences, e.g. before, during, or after food.

Background: up until recently my timing was wake up, Lansoprazole, 30mins, breakfast, 30 mins, then dispersible Aspirin, Bisoprolol, and Eplerenone.

Some technical reading here: pubmed.ncbi.nlm.nih.gov/277... which suggests that timing was important in that study population.

[Lowerfield_no_more]

I take enteric coated low dose aspirin and have done since the dispersible would have caused me gastric problems. They are not digested in the stomach due to the coating but further down the digestive system and so there is no need to be cautious about taking them with food, but if you want to I am sure that would be OK. Otherwise in my view any time of the day is fine so long as its more or less the same time each day, although the NHS advise not to take them within 2 hours of any indigestion remedy. I take mine in the middle of the day. Apparently there is some evidence to suggest that they are slightly less effective than the dispersible sort, but in my case that is an acceptable trade off against the problems I would face if took the dispersible type.

[Happyrosie]

as Lowerfield says. My husband has been on these for some 22 years and takes Lans. (Or something similar) then 30 to 60 min break then all the other tabs including enteric coated aspirin.THEN breakfast.

[Weetabixie]

Hi STEMI _Dave, I was on dispersible but was changed to Enteric coated as I have GORD or GERD and could not tolerate it. I take lansaprazole then half hour later I take clopidogrel, aspirin and bisoprolol with breakfast. Hope that helps 🤗

[annpavitt250448]

My prescription for enteric coated aspirin says take them with it just after food, so I take mine at breakfast. Got my doctor to change mine over from dispersable as I was getting acid reflux again Have mild erosive gastritis. When I went for pre assessment for getting a total knee replacement found I was iron deficient. So had iron infusion, c.t. Colonography and endoscopy which showed up no sign of bleeding, so I am convinced the aspirin and pantoprezole I take are the cause.

[STEMI_Dave in reply to annpavitt250448]

Thanks! You have an interesting point about iron deficiency. I was wondering if PPIs (pantoprezole in your case, lansoprazole in mine) affect nutrition uptake.

[annpavitt250448]

Got a g.p appointment on Monday to discuss scan results, not that he can tell me anything I didn't already know, having had an endoscopy 6 years ago which picked up the gastritis ( caused I think of years taking diclofenic) before I had a hip replacement 22 years ago. Also had co!endoscopy last Feb which just picked up a few pockets of diverticular. I intend to ask whether the iron deficiency could be caused by the p.p.I and aspirin. Also going to ask if I could be vitamin B12 deficient, as I understand the p.p.I can deplete your vit. B12 and also cause not to absorb iron so efficiently

[Naana16 in reply to annpavitt250448]

Thanks for sharing

there are long term risks associated with the use of PPIs

Low Magnesium Levels (e.g., fatigue, muscle cramps, dizziness).

• Vitamin B12 Deficiency (e.g., tiredness, tingling in hands or feet).

• Bone Weakness or Fractures (especially if you’re older or at risk of osteoporosis).

However there are also other causes for low b12 especially in the uk - inadequate dietary intake , long term use of other medications such as metformin

[annpavitt250448]

I did ask for my vitB12 to be checked and it was,fine. Never did find out the cause of low iron. I do eat a moderate amount of red meat as can't stand kale or spinach which do have a good amount of iron.We have a good variety of protein, chicken, fish ( at least twice a week. One of which is an oily fish) and if we have red meat it tends to be in smaller amounts these days.