ibrufin after angioplasty

[Anynomous]

I had angioplasty 6 months ago and I accidentally took 400mg (2 tablets) of ibrufin today . Do I need to worry?

[Anynomous]

Thanks thatwasunexpected , I am kept at low risk by GP I assume and did not have any major symptoms so far.

[JennyRx]

400mg as a single dose isn’t really an issue. But ongoingly may cause gastric bleeds if you’re on antiplatelets like aspirin, clopidogrel or ticagrelor. Also there’s some evidence that ibuprofen can diminish aspirin’s antiplatelet effect. It can also elevate blood pressure in some people. So I wouldn’t worry. And just remember to avoid for the future (pharmacist here)

[Hidden in reply to JennyRx]

I had a serious stomach bleed and was really ill as a consequence caused by taking ibuprofen over a few days, and was borderline requiring a blood transfusion. Consequently I have nothing to do with it. And recently a friend found he was allergic to taking it, his lips and face were swollen. Steer clear of it is my advice. If paracetamol works for you use that, or as I try and do avoid 'painkillers' all together unless absolutely necessary.

[JennyRx in reply to Hidden]

Those responses do happen, but are generally rare. But frightening when they do happen. They are listed on the info leaflet. Most people don’t read that because most people don’t have that sort of reaction. But paracetamol has a much narrower window of safety than most people realise. It’s very easy to accidentally overdose. Nothing is totally safe.

[Anynomous in reply to JennyRx]

yeah , thanks jennyrx

[fishonabike]

in addition to Jenny Rx's advice, i will add that studies so far indicate that the risk is largely with ongoing use of NSAIDs - a single dose is not a problem (unless you are allergic to them and that is clearly not the case for you!)

[Anynomous in reply to fishonabike]

thanks fishonabike

[Hidden in reply to fishonabike]

As I mentioned above I had stomach bleed as a result of taking ibuprofen. In my case 'ongoing use' was for a few days only all within the prescribed limits. Terrible stuff, stay well clear!

[fishonabike in reply to Hidden]

sadly this is a known side effect of NSAIDs (and Aspirin), but it does not affect everyone that way - it is also the reason for the recommendation that it should be taken after a meal or with food and not on an empty stomach - there are also enteric coated versions avaliable for that reason - when prescribed by doctors they also prescribe a proton pump inhibitor like omeprazole

[Hidden in reply to fishonabike]

Which is why I insisted on enteric coated low dose aspirin, although what that is doing further down my digestive tract is anyone's guess 😆

[JennyRx in reply to Hidden]

in the only issue is enteric coated aspirin has a much reduced antiplatelet effect. Although I take it because I don’t want to be on a PPI regularly as it can cause osteoporosis and I’m on cancer treatment that can cause the same. So it’s a balancing act.

[fishonabike in reply to Hidden]

there are suggestions that by altering the acidity levels in the stomach the gut mcrobiome further down the line is affect, with variable consequences

[Anynomous]

thanks aaq91