Another study supporting Niagen for Ataxia.

[sunvox]

Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuro- protection in Spinocerebellar Ataxia Type 7

pubmed.ncbi.nlm.nih.gov/318...

I'm just about to walk my dogs so this post will be short. The article above is behind a paywall, but I purchased it and will share it with anyone who asks. Long story short the study is saying what I have been saying for years. The fact that NIAGEN boosts Sirt1 activity is key, and that fact separates Niagen from all other forms of vitamin B3 which are Sirt1 inhibitors, AND Niagen is likely helpful for many, many central nervous disorders, AND this activity is due to Niagen's ability to dramatically boost NAD+ production in humans.

One interesting fact from this study was that although they actually tested Niagen in mouse models of SCA7, they also tested human brains (post mortem) for signs that what they were seeing in mice as the problem that was fixed by Niagen did in fact occur in humans as well.

Anyways, more later.

Cheers,

Joe in NY

[Rhiny99]

Thank you for sharing; I always look forward to your posts!

[Namitaytrev]

Hi Joe- could you forward me a copy of the study? Great news! Ihave been taking Niagen for 2 1/2 yrs now. I’ll email you so you have my email to respond.

[sunvox in reply to Namitaytrev]

Hi Nami-

Of course, I will send it right away

EDIT: I asked about your B12 intake, but I was confusing B12 and B1 for a second . . . silly me.

Also, when next you see your doctor would you mind asking why he feels so strongly about Ubiquinol?

Thanks a bunch,

Joe

[kuchee in reply to Namitaytrev]

Good day Nami! could you pls. share your view of using Niagen? wondering if you can help finding the suppl. (niagen) in Pakistan. I have SCA1. Thought of having positive after using. I am positive.

[ww-wibblywobbly]

Do you have SCA 7 sunvox?

[sunvox in reply to ww-wibblywobbly]

Hi Alison,

No, I have SCA1, but SCA7 is so very similar, and the study actually examined a cellular process that is similarly broken in many neurological disorders. That is one reason why Niagen is in multiple human clinical trials for several different disorders including, Parkinson's and Mitochondrial Myopathy

I have read your posts on your hard work going to therapy for a decade now, and I can think of few people on this forum who can offer better inspiration to get out there and do the best they can. You inspire us all

Joe

[Happyfacexx]

Thanks for sharing I’m about to order some

[kuchee]

Hi Joe,

Appreciate your input to forum as always. Can you share the article with me please?

[Hidden]

Where do you guys buy Niagen?

[Rhiny99 in reply to Hidden]

Tru Niagen has a website. They did offer a special not too long ago. You can also buy from amazon. It is expensive.

[simon111]

Hi Joe

Will it benefit friedrichs ataxia

Thank you

[cocobibi]

thanks for sharing this info, I'd love to see this and pass it on to the consultant too. Do you know if it's also effective for SCA2 by any chance. My husband is ready to try anything.

Does anyone have any experience/good result from complementary therapies and if so which ones?

Many thanks,

[SilentEchoes]

I would like to read the article. I have MND/ALS, and one of my disabilities is sensory ataxia.

With gratitude,

SE

[kuchee in reply to SilentEchoes]

Hi SE,

Could you share the symptoms for sensory ataxia and how you are coping with it?

I have unknown SCA with sensory effects and I am trying dealing with my daily regimen of medicine and exercise.

Thanks a lot.

[SilentEchoes in reply to kuchee]

For ataxia, you do the Romberg test. Stand with your back to a corner and put a chair in front of you without touching either one. The idea is to protect yourself from falling if you lose your balance while doing the test. Stay safe. You stand still with your feet together and arms at your side for 30 seconds. Do you sway? Now close your eyes. What happens? For me, closing my eyes causes severe swaying, it's loss of proprioception, the sense of where your body is located in space. This is called sensory ataxia.

I start physical therapy next month, there is evidence that the brain can be retrained and ataxic symptoms improved.

SE

[kuchee in reply to SilentEchoes]

Thanks a lot for feedback and yes the swaying symptoms are there too.

I am having heavy steps while walking and can't jump a little high too.

Balance problem while walking seems drunk.

Any advice on meds, supplements or exercise would be highly appreciated.

My current supp regimen includes;

> 1 g, Thiamine (recently commenced) (AM/PM)

> 100 mg, COQ10 (AM)

> 300 mg, GABARDINE (PM), for sensory ataxia

> Turmeric powder Tea (AM)

> Vitamin D

+ 6-Day week 30 min. trade mil, STRENGTHENING, YOGA, Meditation.

I feel much improved than was 6 month before but only having few/ above symptoms. Trying to overcome those too.

Thanks for advice.

[SilentEchoes in reply to kuchee]

What is unknown SCA? I thought SCA was genetic and confirmed by testing. Are you certain it's not a different neuromuscular disease?

You should also look into sulforaphane from broccoli sprouts.

[kuchee in reply to SilentEchoes]

The unknown mean i didn't have any tests as gene testing was not recommended by my neurologist but this genetic mutation as from my mother.

By symptoms and having some research I realize that i have SCA1 with sensory effects.

Kindly elaborate your experience for SALFORAPHANE, as this is my current list of research.

Many thanks

[ilhana]

Please send me the report and if you would be kind enough to tell me which niagen - what brand? Thanks for your help

[Rhiny99 in reply to ilhana]

Sunvox has been banned from this forum so he can’t respond. Tru Niagen has a website and you can purchase from Amazon. I have been taking this along with other supplements and can report that my early symptoms have improved. But please consult your physician.

[ilhana in reply to Rhiny99]

Why has he been banned? Thank you,I will consult my doctor. What other supplements do you take? Thank You again

[Rhiny99 in reply to ilhana]

Look at the forum’s latest posts and you can read about it.

Vitamin b12

Calcium with D

Curcumin

Vitamin e

High dose thiamine (b1)

Taurine

Tru Niagen

Trehahose or Xylitol with my coffee

Magnesium at night for cramps

Exercise and yoga daily

[ilhana in reply to Rhiny99]

Thank you so much

[Rhiny99 in reply to ilhana]

I also take ubiquinol (coq10)

[ilhana in reply to Rhiny99]

Thank you!

[ilhana]

Rhiny99 pls can I have your email thanks

[Rhiny99 in reply to ilhana]

You can send me a pm. I’m sorry, I’m not comfortable sharing my email address at the moment. Take care.

[ilhana in reply to Rhiny99]

I just wanted to know what Brands you take and how much of the supplements and share with you my regimen. I also take supplement like ubicinol, pqq, tumeric, melatonin etc some of yours but not all, Accupuncture, Bioresonance, rTMS,biofeedback , Has see functional dr exercise and do weights, pray

[ilhana in reply to Rhiny99]

Can you Tell me what Brand’s and amounts pls? Sunvox also recommends thiamine how much and what brand?

[ilhana]

I just wanted to know what Brands you take and how much of the supplements and share with you my regimen. I also take supplement like ubicinol, pqq, tumeric, melatonin etc some of yours but not all, Accupuncture, Bioresonance, rTMS,biofeedback , Has see functional dr exercise and do weights, pray

[ilhana in reply to ilhana]

This is for rhiny99