Oxford vaccine stimulates broad antibody and T cell functions.

[2greys]

Today, researchers from the University of Oxford have published further data from the Phase I/II clinical trials of the ChAdOx1 nCoV-19 coronavirus vaccine, evidencing the decision to move to a two-dose regimen in ongoing phase III trials, and how ChAdOx1 nCov-19 is induces broad antibody and T cell functions.

These findings are reported in two papers, both released in the peer-reviewed journal Nature Medicine.

Previous studies have shown that in order to develop any vaccine against SARS-CoV-2 coronavirus, two key elements of the immune system need to be activated: a neutralising antibody against the coronavirus spike protein which is likely to be critically important in protecting against the disease, as well as robust T cell responses.

Professor Katie Ewer, a lead author of one of the papers, said:

‘This highly detailed analysis of the immune responses to ChAdOx1 nCoV-19 further underpins the potential of this vaccine to induce protection against COVID-19 disease and provides additional reassurance of the safety of this approach.’

ox.ac.uk/news/2020-12-17-ox...

Nature Medicine. Both Research Papers:

nature.com/articles/s41591-...

&

nature.com/articles/s41591-...

[sassy59]

Excellent xx

[Badbessie]

To be honest I think this vaccine will be the game changer for the UK.

[Hidden]

I don’t understand it all, but I’ve followed news of the Ox/AZ one all along & am really keen to have it. I have an immune deficiency. so this is reassuring. Anyway I can’t have the Pfizer one atm as I have an Epipen! Thanks

[Kate0307]

Keeping us up to date as always..thank you!

[Hidden]

Good news Xx

[teenieleek]

Do we know yet whether it will effective for those over 55?

[2greys in reply to teenieleek]

The trials with two full sized doses produced a good response across all the ages. The trials, discovered by mistake, to have a greater efficacy with a half dose first followed by a full dose, did not have over 55s in the volunteer group. I would think that if there were over 65s in the 1/2 + full dose group the findings have a good chance of having the same results. But I am not a virologist, the 3rd phase trials were extended to confirm the results of the 1/2 + full dose results and I would think that older people would be included in that.

If given a choice it is my preferred vaccine, it is being predicted that our group of vulnerable people will start to be given a vaccine sometime in February.

[teenieleek]

Thank you. Can’t come soon enough.

[Walkwalkwalk]

Thank you 2greys.

Yes this would also be my preferred vaccine so the next lot of the research will be interesting. Friends around me are being offered a vaccine purely on age Being 3 months short of the 80year old threshold its possible that the Oxford vaccine will have registration by the time one is offered.