Interim results of the Oxford COVID-19 vaccine trials find that the vaccine protects against symptomatic disease in 70% of cases—with vaccine efficacy of 62% for those given two full doses, and of 90% in those given a half then a full dose (both trial arms pre-specified in the pooled analysis). The results are the first full peer-reviewed efficacy results to be published for any COVID-19 vaccine, and are published in The Lancet.
The vaccine was found to be safe, with only three out of 23,745 participants over a median of 3.4 months experiencing serious adverse events that were possibly related to a vaccine; one in the vaccine arm, one in the control arm, and one in a participant who remains masked to group allocation. All participants have recovered or are recovering, and remain in the trial.
Study author, Dr. Merryn Voysey, University of Oxford, UK, says: "The results presented in this report provide the key findings from our first interim analysis. In future analyses, with more data included as it becomes available, we will investigate differences in key subgroups such as older adults, various ethnicities, doses, timing of booster vaccines, and we will determine which immune responses equate to protection from infection or disease."
There does appear to be an alarmingly small number in the over 49 yrs old group?and no apparent explanation as to why this was so given that they are the ones most likely to develope a severe reaction requiring hospitalisation?
It was the accidental low dose followed by the high dose group which gave the 90% efficacy result that did not contain the over 55s. If it was safe in the high followed by another high dose group that did contain over 55s then it will still be safe in the low dose first. The result of the omission of facts in the press, who rely on headlines to sell their papers. Not exactly a downright lie (fake news) as such, but a distortion of the real facts.
Nobody is doubting its efficasy but many scientists have not been impressed with the manner and the timing that Astra Zeneca have presented evidence during the trials.one of the many reasons why until further trials are competed in the USA the FDA will not clear it for use at the present time,eventually i don't doubt they will once those are completed but they will need to improve their procedures and presentations in the future in my opinion.
It does not alter the fact that the data has been peer reviewed by scientists worldwide and the only one to be peer reviewed. Not really remarkable for America not to accept the data for a British vaccine before the American Pfizer vaccine. I believe America is still a capitalist country.
Given that America have already pre ordered several hundred million doses of the Oxford/Astra Zeneca vaccine it is hardly in their interests to stall it's regulatory acceptance.like you i initially considered that America was protecting it's own interests but Astra Zeneca have fouled up on several occasions with the FDA during their trials with data submission and accurracy,albeit unintentially and they need to get their act together.
The outgoing President turned down an offer to buy an additional 100 million doses of the Pfizer vaccine in a special deal, if the Moderna vaccine does not pan out, then they will be up a gum tree
It was the accidental low dose followed by the high dose group which gave the 90% efficacy result that did not contain the over 55s. If it was safe in the high followed by another high dose group that did contain over 55s then it will still be safe in the low dose first. The result of the omission of facts in the press, who rely on headlines to sell their papers. Not exactly a downright lie (fake news) as such, but a distortion of the real facts.
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Has Plan B been completely scrapped?
Oxford vaccine 
