Methotrexate

[cba84]

Been on methotrexate by weekly injection for about 18 months. Always suffered from the fatigue the day after but this seems to becoming increasingly worse. I’m already on b12 injections and these don’t seem to have made any difference but just feel completely wiped out for two days. No matter how much I sleep I still the fatigue is winning. Has anyone else suffered increased side effects? If so have you any advice? Thanks in advance.

[Batty1]

I don’t take methotrexate but I have been on cosentyx for over 3 years now and Im also suffering with a much longer bout of fatigue after the injections then I did previously.

Its weird and I have no explanation.

[nutta]

My wife is on methotrexate injections (methojet) also. She is actually fatigued most of the time and in fact has bouts of passing out. This too, is increasingly so. Her fatigue seems to be quite permanent now.

Perhaps you could head it off before it comes to this, I don’t know. It may be something to take up with your GP in the first instance and hopefully, do something about it. I’m not even sure if her fatigue is down to the methotrexate, but it’s worth considering. She has been on hers in injection form, for about four years or so now.

I’m sorry I can’t offer any advice, but it certainly strikes a chord due to the similarity of the effect. I hadn’t made the link with methotrexate until I saw this, so I’m going to contact her GP and suggest there could be a link.

[Hoping2]

Try iron vitamins I have the fatigue pretty constantly but find iron tablets have helped

[Ebtvet]

Hi... ive only been on methotrexate for 7 weeks.... tablets once a week, followed by folic acid 2 days after.... the first few weeks I felt nausea and vert tired.... I was told to try taking the folic acid 6 days a week and not on the day of methotrexate.... made a massive difference.... no nausea and definitely not as tired....

[Jessiedog67]

Sorry there is no good advice, I've been on methotrexate for about 6 years along with a biological drug, it doesn't get any better you have to learn to pace yourself and slow down, easier said than done I know, but it was the best advice I was given, and stop when your body tells you too. It makes life difficult not just for you but those around you as they do not fully understand the implications of fatigue. This disease and its medication are cruel, but, please persevere with your meds and don't give in, you will win in your own way, best of luck.