Nervonic acid

[Yevgenii]

Have anyone tried taking Nervonic Acid? The following article showing benefits from NA neurotherapeuticsjournal.or....

I heard it's common in China. Is there anyone from China?

[monmon]

I don’t know about China but it’s definitely used in Italy as a ALD/AMN supplement. In the UK (where I live) it’s impossible to find. I’d also be curious to know of people’s experience in other countries.

[Djp1989 in reply to monmon]

Do you know where in Italy? I have family there. May look into it.

[Djp1989]

problem is finding that from a reputable source and dosages. And yes it is common in China. There was never a human trial done that I am aware of

[Yevgenii in reply to Djp1989]

Do you any reputable manufacturers of nervonic acid from China? China is pretty close to me, so I'd like to order some

[Djp1989 in reply to Yevgenii]

I don't sorry. I found some pharmacies in Italy though. I have to look into getting it since I am american. I was just in italy in august wish I would've known lol

[monmon in reply to Djp1989]

Sorry I don’t either. I’ll be in Italy for Xmas, I’ll find out more ☺️

[Djp1989]

link.springer.com/article/1...

[tetris]

I'm not sure that nervonic acid would help, nervonic acid does not cross the blood-brain barrier, so it probably won't affect your brain, your spine, or your nerves.

> These results established that NA does not cross the blood-brain barrier in this form.

patents.google.com/patent/U...

[Yevgenii in reply to tetris]

Different sources say different things. So at least it worths to try

[Djp1989 in reply to tetris]

tetris if you continue reading it says it crosses the blood-brain barrier in other forms "NA:GLA". There was a more recent study specifically for AMN I linked above. Basically they need to do human trial

[Yevgenii in reply to Djp1989]

Thank you. I found this one too. But manufacturer seem to has bad reviews. Didn't make decision to order it yet.

[Djp1989 in reply to Yevgenii]

Here's the direct source: sinavita.shop/en/p/nervonsa...

Lot cheaper. I bought 4 bottles 😅

[tetris in reply to Djp1989]

> tetris if you continue reading it says it crosses the blood-brain barrier in other forms "NA:GLA".

What I linked to was a patent, and NA:GLA is what they're patenting. So unless you find a way around that, when you buy a nervonic acid supplement, you are not getting the patented special form that can cross the blood-brain barrier.

> There was a more recent study specifically for AMN I linked above.

Above, you linked an experiment on adrenoleukodystrophic fibroblasts. Experiments on fibroblasts bypass the blood-brain barrier completely, and there are numerous studies out there about different substances that are affective on adrenoleukodystrophic fibroblasts, yet are ineffective on humans, and in many cases, the difference is the introduction of the blood-brain barrier.

Bezafibrate, for example, was effective on fibroblasts: researchgate.net/publicatio...

> We recently showed that bezafibrate (BF), a drug used for the treatment of hyperlipidaemia, reduces VLCFA accumulation in X-ALD fibroblasts by inhibiting ELOVL1, an enzyme involved in the VLCFA synthesis.

but ineffective on humans:

> We concluded that BF, at least in the dose given, is unable to lower VLCFA levels in plasma or lymphocytes in X-ALD patients. [...] BF appears to have no therapeutic utility in X-ALD.

Bezafibrate crosses the blood-brain barrier very slowly, so this result is not surprising.

I agree that nervonic acid could be very promising, but not in the form that is currently available over-the-counter as a supplement.

[Fumaniron]

it’s on my radar….

[Djp1989]

Here's a seller out of UK. The supplier is German: eliveragroup.com/products/n...

Ships worldwide

[Djp1989]

Or direct: sinavita.shop/en/p/nervonsa...

[cips]

Im taking 250 mg daily of nervonic acid. Will do a VLCFA blood test soon and will let you know if its normalized or not