Baicalein 5,6,7-trimethyl ether, a flavonoid derivative, stimulates fatty acid β-oxidation in skin fibroblasts of X-ALD

[monkeybus]

sciencedirect.com/science/a...

This is interesting. Getting old but it shows promise.

The purpose of the present study is to identify bioactive compounds with potential for X-linked adrenoleukodystrophy (X-ALD) pharmacological therapy. Various plant natural products including flavonoids were tested for their ability to ameliorate the abnormality of very long chain fatty acid (VLCFA) metabolism in cultured skin-fibroblasts from X-ALD patients. Of the compounds tested, baicalein 5,6,7-trimethyl ether (baicalein-tri-Me) was found to significantly stimulate the VLCFA β-oxidation activity. Furthermore, the incorporation of [1-14C]lignoceric acid into cholesteryl esters was markedly reduced towards the normal level and the VLCFA (C24:0 and C26:0) content was decreased. These results make baicalein-tri-Me a candidate for the therapeutic compound for X-ALD.

And Baicalein is available OTC as well. Have a read, folks.

There are a lot of candidates for upregulating ABCD2 and/or halting the elongation of VLCFA. I tend to stop researching, then go through bursts of activity with all this. Being cursed with fatigue certainly doesn't help matters any.