4-aminopyridine-3-methanol (4-AP-3-MeOH).

[monkeybus]

I have a lot of time for 4-aminopyridine, and despite a lot (most) of my posts being about drugs, I really am not a drug person.

I've been taking more and more 4-aminopyridine lately and generally I tolerate it well, but at times it's like a mild pins-and needles mostly over my face. I can live with it. Probably I take 60-80mg per day. It works.

Anyway, I've been taking a fair amount of 4-aminopyridine-3-methanol of late and it's a completely different animal. Very pleasant (if that's the right word). It comes on quite slow compared with 4-AP. At first I wondered if I was wasting my money.

No, it's good. And low doses as well. I'm lucky to do 5mg in one day. My balance is excellent, much reduced spasticity, achey legs are better. Popped out to the shops earlier and ended up doing a 2 hour bike ride.

I can't be the only one who takes this, though at times it seems so.

My spasticity comes and goes in cycles. Today was shaping up to be a bad spasticity day. Not now. I've been taking a lot of L-threonine as well, and Aspirin for circulation, and I've started wearing compression stockings again as well.

I've this week stopped with the Gabapentin, I enjoyed the spasticity reduction, but the next day the spasticity was over double "usual" levels. Kept on redosing to avoid the comedown. I was relieved to see the last of all that.

All this adds up to greatly reduced spasticity. My wife was reading about a Russian billionaire who is planning to have his head transplanted onto a donor body. If only I had that kind of cash

[bsc78]

I've been taking 4-aminopyridine for sometime as well with success. At first, I paid for the brand name. Without insurance willing to pay for it, at $1700/mo for 10mg/twice a day, it was not a feasible treatment. I began having it compounded at a reputable pharmacy. I still experience the benefits of reduced spasticity and increased gait flow. I don't know about the "3-methanol" part though. I'm not sure I'm getting that variant of the drug. I do know that I'm taking a slow release type. Interested to hear whether you experienced greater benefits with increased dosage.

[tieaknot]

Wow! I was just reading some very promising studies on it (albeit on guinea pigs but hey!) and was excited to see that you have tried it! Where do you get it?

Does your neuro prescribe it? Do you have it compounded? None of my docs have ever mentioned it as an option...they actually haven't offered much of anything...I guess I am not "severely affected" enough but my view is why wait until more damage is done before trying to restore function or prevent further degeneration. Thanks!

[monkeybus in reply to tieaknot]

mod4alll.com/zc11/index.php...

There's the link. 1mg does me all day. That's quite a step down from 30+mg of 4-ap.

I might open the capsule up and split it in half actually.

It really helps with my fatigue as well (taking much less Modafinil).

Life had been getting to me a bit lately. Walking is hard and stressful at times. Not now, well not so much.

[monkeybus in reply to tieaknot]

I asked my neurologist for 4-aminopyridine, no chance. I told him I'd aquire my own, he said no problem.

Same story for 4-AP-meoh. He'd never heard of that, wasn't the least but interested in hearing about it from me.

My final words "Can I have some Valium?"

He had heard of that, he prescribed it without even asking why I wanted it.

[tieaknot in reply to monkeybus]

I am near tears reading this. It is just so frustrating. We are desperate for answers, for guidance, for help...and unless big pharma is getting $, we get shrugged off or given meds that rarely help without rotten side effects. Thank God for forums like this where we can help each other find answers. I am hoping to try this compound as well as investigate CBD and bee propolus. I have to hold out hope that something will help...for all of us and our loved ones.

[monkeybus in reply to tieaknot]

Yes, CBD is next on my list.

Met a friend today who I haven't seen for months. He was amazed at my walking abilities. I even managed a little dance for him.

Didn't know about bee propolis. I'll have a look at that.

[tieaknot in reply to monkeybus]

The active component in bee propolis is caffeine acid...check it out...interesting stuff. I might have to become a bee-keeping cannabis horticulturist when it is eventually legalized. Those will be some HAPPY chilled out bees! 😉

[tieaknot]

Thank you so much. So ordering off that website is legit? I am in the USA. I always worry that online pharmacy may be a scam, but there seems to be no other way to get it! (Unless you're a guinea pig!) I couldn't find how many capsules come in the order...for $100, I would hope a decent supply. I appreciate your help!

[monkeybus in reply to tieaknot]

100 capsules.

I've been buying from them for ages, mostly Modafinil.

They were my 4-aminopyridine supplier for a long time as well.

I trust them. Never let me down.

I really do recommend the 4-AP-meoh though. I can even walk downstairs reasonably quickly now.

[tieaknot]

Thanks again! I will report back when I try them!

[DennyB]

I asked my neurologist about it. He told me they would supply free of charge for the first month and then $700 per month after that. I understand that it can be of a big help, but could not afford that amount. It's a bugger when it comes down to cost and not what is best for the patient.

[monkeybus]

$700.

Seven hundred.

Little wonder I buy mine online.

[kazza100]

Hi there,

Just came across this site whilst doing some research for my husband.

He has myelin damage on his spinal cord due to a car accident,this causes the electrical signals to his legs to be spasmodic therefore he has major difficulty walking.

I noticed that you take 4-aminopyridine-3-methanol and thought after reading the articles on this drug that it may benefit him.

You are the only person I have found that actually takes this so I'm hoping that you could give me the benefit of your knowledge !

Is it safe to buy off the internet ?

Do you suffer any of the side effects ?

As you know,the worry of buying pills off the internet and just taking them is huge !! So any insight and peace of mind you could give would be greatly appreciated.

Thanks ever so much

Kazza100

[monkeybus in reply to kazza100]

I'm sick and tired of all the drugs. Really trying to cut down on my Modafinil use.

To be fair, the 4-AP-meoh, for me has fewer side effects than regular 4-aminopyridine.

I posted about it recently on someone's blog, I've taken enormous quantities of 4-AP-meoh. Other users in Australia have as well.

I'll post some links tomorrow.

All the best for your husband, Kazaa100.

[Casabona in reply to monkeybus]

Hi monkey bus

I have AMN and I am in Brisbane. Is there any chance to chat with you about 4-aminopyridine-3-methanol and your experience. I am nervous about ordering from mod4all directly (not just the cost but getting through customs etc.) and I believe it alone works for about 30% of people.

Casabona

[monkeybus in reply to Casabona]

Hello Casabona,

I can't recommend 4-AP-MeOH highly enough. Quite a few people swear by it.

Do you take 4-ap/Ampyra currently?

[drfreudine]

Hi, is this discussion still active? Anybody getting 4-AP-3-MEOH? Mod4all doesn't seem to be responding to emails. Thanks so much!

[monkeybus in reply to drfreudine]

I'll reactivate this thread.

Mod4all site is down at the moment. I mailed them, back up very soon.

I received some 4-AP-3-MeOH a couple of weeks ago. Just as good.

tieaknot mentioned Propolis, which is indeed interesting stuff. A health supplement like no other.

I want some. I'm getting some.

[dirtchic]

Where do you buy your 4-ap-3-meoh

[monkeybus in reply to dirtchic]

Hello,

Forgot I wrote this post. Years ago now.

I still get my 4-ap-3-meoh from mod4alll.com

Though I see it's marked as sold out. Just email them, they still have it. Myself and several other people I know buy regularly.

I see they sell that Ampyra generic, Dalstep as well now. Have any of us tried that? Expensive as hell, that Ampyra.

[dirtchic2 in reply to monkeybus]

Thank you. I'm waiting for their reply.

[dirtchic2]

where can i buy 4-ap-3-meoh