How did you get started BAT and what would you suggest to someone looking to try this threapy

[Apd66]

check my bio for history. I’m getting close to the “why not” try. My MO is hesitant, wants to go another round of Pluvicto (I was successfully treated about a year ago) oranother round of Chemotherapy. Although I do not think he is wrong, my opinion is these therapies would still be available should the BAT fail. There are some trials that combine therapies with BAT, that I would also entertain. I just don’t know how to get started. Just had a new Guardiant blood test and awaiting approval for a fresh PSMA PET. Figured anywhere I start would be needing newest information. My thought was to treat a few painful spots with SBRT, then start the BAT. Maybe someone has already done this or knows of a trial that would include both. My current treatment utilizing PARP inhibitor Lynparza is failing.

I’ve seen here that most went through Dr. Denmeade at John’s Hopkins. Is this the most popular way? How does one initiate this process?

[Tall_Allen]

Many men (about ⅓) seem to get much worse on BAT. It is not a "Hail Mary" play -- it is potentially very dangerous. Johns Hopkins may have created a test to find out if it may work. You should not do it outside of a clinical trial. And it has never been done in trials in men who have had bone pain -- you would not be accepted into a trial.

[Apd66 in reply to Tall_Allen]

Do you feel bone pain is limiting for any BAT trial?

[Tall_Allen in reply to Apd66]

All BAT trials that I am aware of exclude patients that have had bone pain or any other metastatic symptoms.

[j-o-h-n]

Do a search of our H.U. History file (see top left of screen) for tons of information/posts regarding "experiences with Olaparib".

Good Luck, Good Health and Good Humor.

j-o-h-n

[MateoBeach]

It is very easy to do a test run of BAT to see if you are a favorable responder, or not. It just involves getting a 400 mg shot of testosterone cypionate every 28 days for 2-3 cycles and following PSA levels especially at the end of the cycles. A video consult with Dr. Denmeade would be good to put you and your MO at ease. This is very inexpensive so you don’t really need a formal trial to test it

[Apd66 in reply to MateoBeach]

Have you participated yourself? Tall Allan’s remarks about exclusion maybe takes this off the table. I have had bone pain since DX. It was what drove me to the hospital wondering what was wrong. My options are growing fewer within SOC. I’m trying to hang on enough to get in on immunotherapy trials, preferably p2 or p3. Im in Florida

[MateoBeach]

I have been on BAT for over 4 years and it works extremely well for me. PSA undetectable for past three years. Bone pain is not a compete contraindication, depends on where and how severe as it can flare up when starting BAT. Worth having Denmeade review your case.

[RoseDoc]

BAT is, potentially, very dangerous. I would do it under the guise of someone who is very experienced in this. Dr. Denmeade at Hopkins seems to be the one with the most expertise in this treatment. How do you start the process? Give his office a call, send any records they may want, make the appointment for a consult.