Update on Dad

[Giuliamen]

Hi all, my dad (68) was diagnosed with high volume metastatic stage 4 PCa in November 2024. He was put on Decapeptyl injections every 3 months, and started triplet therapy in January (darolutamide + docetaxel).

I wanted to share some updates and ask for your opinions on his progress:

November 2024: initial PSA of 1,048. Decapeptyl injection + bicalutamide.

January 2025: PSA dropped to 28. Started triplet therapy.

After two docetaxel infusions, PSA dropped to 11.

Alkaline phosphatase is dropping too, but remains at around 400. I love my dad so much. Any thoughts would be greatly appreciated!

[Tall_Allen]

Congratulations on his early success!

[Giuliamen in reply to Tall_Allen]

Thank you so much! Grateful for all the advice from this community. I wouldn’t have insisted for triplet therapy without the encouragement and support I got from here.

[LuvLapsang]

Praying for your father and your family that he will continue to have such a positive outcome on his treatment regimen. Your love and support for him will go a long way.

[Giuliamen in reply to LuvLapsang]

Thank you! He’s always been healthy overall and he’s not a big fan of medicines, so I am trying to support him as best as I can.

[lcfcpolo]

Excellent response. Hopefully the PSA keeps dropping now and remains low for many years.

[Giuliamen in reply to lcfcpolo]

Thank you! Fingers crossed.

[GP24]

Adding Xofigo or Pluvicto would work well but these are not approved right after being diagnosed.

[Giuliamen in reply to GP24]

Thank you for your advice. Perhaps we can start discussing these options after he is done with his 6 rounds of chemotherapy.

[speranza10 in reply to Giuliamen]

Unfortunately in Italy it doesn't work like in the United States, these combinations are not approved, at least for now.

[GP24 in reply to Giuliamen]

You will have to find a nuclear doctor who is willing to apply this.If you don't I will not be able to help.

[speranza10 in reply to GP24]

Once the 6 cycles of chemo are finished I imagine that your father will continue to take darolutamide. At the moment in Italy it is not possible to add xofigo or pluvicto together with a second line hormonal drug. When darolutamide fails (I hope as late as possible) you can switch to xofigo or pluvicto.

[Giuliamen in reply to speranza10]

Thank you for clarifying it. We haven’t discussed that with the MO yet. Currently looking into bone strengthening infusions.

[JohnInTheMiddle in reply to GP24]

G's Dad is already off to a great start! And it's very possible after chemo that the ongoing doublet therapy will be successful for years! Randomly suggesting adding additional science fiction therapies on top of the current regime now is just irrelevant noise. Do you have any high quality studies supporting your "ideas"? People embarking on this journey after such a recent dire diagnosis need focus, and good information that supports decision making. And, as always, encouragement to exercise 😃.

[RJAMSG]

prayers for successful treatment 🙏🏻

[Giuliamen in reply to RJAMSG]

Thank you so much!

[Hailwood]

Great response. Keep going with your Dad

[Giuliamen in reply to Hailwood]

Thank you so much!

[Professorgary]

Great response. As far as the alp, that can sometimes take a while because it can actually rise while the bones remodel. The fact that it is coming down is great news. God bless.

[Giuliamen in reply to Professorgary]

Thank you so much for clarifying. We were quite worried but that explains the high numbers. Best of luck in your journey!

[Kaliber]

looking good, perfect for spring …. I hope your father’s future treatments are as successful as his current ones.

❤️❤️❤️

[Giuliamen in reply to Kaliber]

Thank you so much ❤️ congratulations on your joinery so far, and wishing you the same!

[j-o-h-n]

to Giuliamen,

Good news keep up with the good work for your dear Dad. Yep, your Dad has it right..... most of us (men that is) hate meds. Now would you please update his bio for his/your use and for ours too. You're a great offspring, and care giver. Thank you, take care, regards from all of us and keep posting!!!

Good Luck, Good Health and Good Humor.

j-o-h-n

[Giuliamen in reply to j-o-h-n]

Thank you so much! Great community and wonderful spirits 😊 I have updated my bio!

[Warra]

Normally I don't participate in discussions. Even though I have strong beliefs, I prefer not to share them because everything has already been said here. I feel a strong bond with all of you. I just want to tell you that your father should go to the hospital immediately if he gets even the slightest fever during docetaxel. Danger of septic shock. Also ask for Neulasta. That keeps the white blood cells somewhat at a level. And a port catheter.So they always can give him every medecine he needs if something goes wrong (docetaxel is heavy stuff). Adt/docetaxel/Xtandi and hope for a breakthrough. I wish you and your father many more good years (at least 10).And who knows what will follow.

Never lose hope.

[Giuliamen in reply to Warra]

Thank you for your kind words. He already has a port catheter and measures his temperature daily. Really appreciated your advice, and I will keep that in mind ❤️