Lupron vs. Erleada

[jackwfrench]

My MO wants me to move to Erleada but is not really explaining why - any ideas?

[MelodyCat]

Is this INSTEAD of Lupron? I am on both as is indicated by any of the studies I have seen. Most monoline therapies don’t show as good results. I am sure others will chime in. By the way, my side effects are not that bad.

[jackwfrench in reply to MelodyCat]

Yes I am also on abiraterone and prednisone, he wants erleada instead of lupron, but why?

[MelodyCat in reply to jackwfrench]

Seems odd to me. lupron stops/slows the production of T via the brain while abiraterone and erleada are both “blockers” to stop synthesis of any remaining T…usually.

[speranza10 in reply to jackwfrench]

It seems strange to me that he wants to change Lupron to Erleada. Is it that you misunderstood and instead he wants to change Zytiga to Erleada?

[Leaffan57 in reply to speranza10]

I'm on Lupron and Erleada...18 months now

[Tall_Allen]

Erleada monotherapy (apa) was tested against abi +ADT and apa+abi They found that apa achieved PSA of ≤0.2 ng/mL in 60%, while abi+ADT achieved 76% and apa+abi achieved 80%. However, serious side effects were seen in only 21% on apa, vs 31% on abi+ADT vs 36% on apa+abi.

ejcancer.com/article/S0959-...

Perhaps your oncologist thinks your risk of serious side effects exceeds the improvement in oncological benefit? This should be discussed.

[jackwfrench in reply to Tall_Allen]

I have to apologize - he was referring to Eligard which I understand is essentially Lupron, I got it mixed up with something else I was reading. Sorry.

[carbide in reply to jackwfrench]

That changes everything! You posted to quickly. Something I could do. Just get better. 👍

[PCaWarrior]

If you tolerate the sides apalutamide plus zytiga is better.

Zytiga stops biosynthesis of T in the adrenals, the testes, and the tumor microenvironment. Whatever is left gets blocked by the ARSI (Erleada).

[AlmostnoHope]

Lupron is awful but worst of all , leads you into CRPC. I prefer Orgovyx because it works far better and its oral so it works with my natural plus medicinal protocol. It makes me tired but I can take breaks intermittently and maintain stable PSA.

[jackwfrench]

Lupron leads to CRPC but Orgovyx does not?

[dhccpa in reply to jackwfrench]

Same question. Haven't heard that before.

[London441]

No.

[RTSON1 in reply to London441]

So is it the Low T condition that allows CRPC to emerge or is this a side effect of specific ADT medications?

[London441]

Medically the answer is multifaceted and a bit complex. Here is a summary:

pmc.ncbi.nlm.nih.gov/articl...

Informally, it's a lot like many other drugs. The body adapts to drug use, whether medicinal or recreational, in a variety of ways. Cancer, as we know, is basically us turning renegade on ourselves. Survival endowed to the max. It adapts to our best efforts to eradicate it. Fascinating, but also a sad-and so far insoluble- process.

Many experts now believe switching therapies periodically helps keep the disease 'off balance', but it is by no means proven to work.

[RTSON1 in reply to London441]

Thanks

[SteveTheJ]

They're two different things that can be taken together. That's how I started in 2020, taking both, and now I've temporarily stopped Lupron.

[j-o-h-n]

Simple Reason:

Your M.O. just invested a ton of money in The Janssen Pharmaceutical Companies of Johnson & Johnson that manufacture Erleada.

Good Luck, Good Health and Good Humor.

j-o-h-n