PSA up from 0.6 in 07/24 to 4.0 in 12/24

[Carr52]

I was diagnosed with Prostrate Cancer in July 2020 PSA 82 and Gleason 9. The Oncologist put me on Bicalutamide 2020 till 2023. Further i had Radiotherapy to prostrate and lymph towards the end of 2020. PSA was 10.5 in Oct 2023. I am on Zoladex from Nov 2023 till date.

My previous PSA was 0.6 in July 2024 and latest PSA was 4.0 Dec 2024. I'm shocked about the sharp increase in the short period. Any likely reason(s) for the spike? What are my options going forward? Many thanks.

[GP24]

You could add Abiraterone and continue with the combination of Zoladex and Abiraterone.

[Carr52 in reply to GP24]

Many thanks for the suggestion.

[VictoryPC]

You likely developed resistance to the Bicalutimide. Now on to the next ones.

[Carr52 in reply to VictoryPC]

I developed resistance to Bicalutamide then on to Zoladex. It seems I’m resistant to that as well. Thanks

[PELHA in reply to VictoryPC]

Bicalutimide didn’t work for my husband either so now on doublet with Erleada and quarterly Lupron shots. Numbers trending down so far so good.

[Tonyliv]

Chemotherapy also still in your arsenal. I started docetaxel last February and switched over to cabazitaxel in July. I’m investigating LU177 presently.

[Carr52 in reply to Tonyliv]

I’m due to see my Oncologist in the new year. All the best with LU177. Take care and thanks

[Tall_Allen]

IDK if NHS allows it, but ideally you'd emulate the EMBARK or PRESTO trials:

prostatecancer.news/2023/05...

prostatecancer.news/2022/09...

[Carr52 in reply to Tall_Allen]

I will have a chat with my Oncologist about the trials. Thanks for the response

[ARIES29]

I am on Zoladex with Nubeqa 600mg day now. PSA came down from 6 to 0.6 in no time but has stopped due to me reducing from 1200mg day to 600mg due to SE.

[Carr52 in reply to ARIES29]

Thanks for the insight. All the best and thanks

[johnscats]

I still have my prostate numerous mets to bones when diagnosed in 2017 465 was psa no chemo no radiation my psa has always been considered high even though it dropped to 1.4 at one stage hovers between 2.2 and up to 6.8 now keep getting a large rise then a massive drop the following month on firmagon only at present scans every six months ct with contrast have had 3 psma scans just finished one 2 days ago no change in mets so I would look for progress before worrying to much best of luck and happy xmas

[Carr52 in reply to johnscats]

I’m due to see the Oncologist in the new year to discuss the way forward. Thanks and Merry Christmas to you and yours.

[Carr52]

Will do. Thanks

[johnscats]

And you buddy hope all goes well actually it will

[j-o-h-n]

Greetings Carr52,

Would you please update your bio. All info is voluntary and it helps you and helps us too. Thank you and Seasons Greetings.

Good Luck, Good Health and Good Humor.

j-o-h-n