High blood sugar while taking a course of Jevtana?

[Newdiag-NC]

Hello Warriors!

After the 5th Jevtana infusion, my husband’s blood sugar was found to be in the 170s. Duke notified him to see a doctor. He has diligently been restricting carbs and sugar but his numbers are still high.

Anyone else encounter this?

Thanks!

[j-o-h-n]

I suggest that you do a search of our H.U. history file (above left) for the string " Jevtana and sugar ".

Good Luck, Good Health and Good Humor.

j-o-h-n

[Newdiag-NC in reply to j-o-h-n]

Hi J-o-h-n! Thank you for your reply! I had done a search but only in advanced PCa, so I tried the wider search you mentioned. I appreciate you referring to where to click…I don’t always do these things the right way! Appreciate you!

[j-o-h-n in reply to Newdiag-NC]

Sherry, You're welcome, and you're a wonderful caregiver for your dear Husband. Keep on keeping on....

Good Luck, Good Health and Good Humor.

j-o-h-n

[CAMPSOUPS]

Of course not an expert me but I'm not so sure I would lean towards Jevtana as the cause. Your hubs been on Lupron and Zytiga for awhile and this has at a minimum been theorized to create glucose disturbances including diabetes. And were getting old too. Can be coincidence.

I dont recall a correlation with chemo. But thats just me.

Regardless I hope he gets some benefit in putting the brakes on his PC.

[Seasid in reply to CAMPSOUPS]

The comment reflects a layperson's perspective on a complex topic: potential side effects of cancer treatments, specifically whether Jevtana (cabazitaxel) chemotherapy could cause glucose disturbances or diabetes. Here's a breakdown of the situation for clarity:

1. Lupron (Leuprolide) and Zytiga (Abiraterone Acetate):

Both are hormonal therapies used in prostate cancer treatment. They work by suppressing testosterone, which can slow the progression of prostate cancer. However, they are associated with metabolic side effects, including insulin resistance, hyperglycemia, and increased risk of developing diabetes.

Lupron: As a GnRH agonist, it lowers testosterone levels, which can disrupt glucose metabolism.

Zytiga: This androgen synthesis inhibitor is often paired with prednisone, which can exacerbate glucose disturbances.

2. Jevtana (Cabazitaxel):

This chemotherapy drug targets advanced prostate cancer, especially when other treatments like docetaxel fail. Its primary side effects include bone marrow suppression, diarrhea, and neuropathy. While chemotherapy can sometimes indirectly influence glucose metabolism through systemic stress or inflammation, Jevtana itself is not strongly linked to diabetes or significant glucose disturbances.

3. Aging and Coincidence:

As the commenter noted, aging itself increases the risk of metabolic disorders like diabetes. It can be challenging to separate treatment side effects from natural aging or coincidental health changes, especially when multiple therapies are involved.

4. Management of Diabetes in Cancer Patients:

Regardless of the cause, managing glucose levels is crucial during cancer treatment. It’s essential to communicate any new symptoms or diagnoses, such as diabetes, with the oncology team to adjust treatment plans or incorporate diabetes management strategies.

The commenter offers a reasonable observation: Lupron and Zytiga are more likely contributors to glucose disturbances than Jevtana. However, they also acknowledge the complexity and potential for coincidence, highlighting the importance of individualized care and hope for treatment efficacy.

ChatGPT said

[CAMPSOUPS in reply to Seasid]

Pretty good summation especially for the poster.

I am the first to fully convey that I am a lay person but somehow I was almost offended at first by AI labeling me as such ha, ha, lol.

[Newdiag-NC in reply to Seasid]

Thanks seasid!!

[Newdiag-NC in reply to CAMPSOUPS]

Thanks CAMPSOUPS! I realized the profile for my husband isn’t clear regarding his current daily meds, so I edited that…I appreciate you reading and replying! He was taken off all PCa meds except for Orgovyx since he became castrate resistant several months ago. Yup! The aging process does unfortunately add ‘excitement’ regarding blood sugar changes! I appreciate your input!!! Thanks for your kind reply!

[Mgtd]

Seasid I enjoy reading your posts which include ChatGPT input. I realize using AI requires a skill of framing a question. That means you also require a certain type of thought process and logic to frame the question.

Would it be possible for you to show the original post that generated your superb posts?

Thanks

[Seasid in reply to Mgtd]

I just copied and pasted the following into ChatGPT.

'CAMPSOUPS

17 hours ago

Of course not an expert me but I'm not so sure I would lean towards Jevtana as the cause. Your hubs been on Lupron and Zytiga for awhile and this has at a minimum been theorized to create glucose disturbances including diabetes. And were getting old too. Can be coincidence.

I dont recall a correlation with chemo. But thats just me.

Regardless I hope he gets some benefit in putting the brakes on his PC."

[Mgtd in reply to Seasid]

Thanks! Now I see what you are doing.