A question about Xtandi

[Poollover]

After Orgovyx and Zytiga have failed is there any evidence Xtandi will help? Terry/Poollover

[DrawingSnowmen]

It's not likely according to the Transformer trial comparing enzalutamide to BAT:

>In those patients who got enzalutamide initially, we had about a 20% response that lasted about three or four months. In the patients who got testosterone first and then enzalutamide, we had about an 80% response, and that lasted about 11 months.

Here's the discussion:

urotoday.com/video-lectures...

[Tall_Allen]

Yes, but not for very long. Simutaneous docetaxel may extend Xtandi's expected benefit, as in the PRESIDE trial.

prostatecancer.news/2022/10...

[RyderLake2]

Hello,

I did it the other way around. I was on Xtandi (enzalutamide) for approximately five years. When that started to fail my medical oncologist put me on Zytiga (abiraterone) plus Prednisone. That worked but only for about a year. While on the ARPI drugs I stayed on my ADT drug, Zoladex. I have been taking it since diagnosis, eleven and a half years, and probably will be taking it for the rest of my life. Start thinking about chemotherapy or a radioligand drug like Lutetium (Pluvicto). Good luck!

[Tinkudi]

I read someone writing on this. I add that Xtandi worked for him for a long while after zytiga failed

[j-o-h-n]

There are truckloads of posts regarding Xtandi in our H.U. history file. Just search it and I would guess that you will find some answers to your question.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Poollover in reply to j-o-h-n]

Thanks John.

[Purplehayz]

my husband had no discernible inprovement from Zytiga. He was switched to Xtandi & changed from Lupron to Orgovyx. He is stage 4 and almost 10 years into the fight and recently had his first undetectable PSA since right after RRP.

[petrig]

How about Nubeqa(darolutamide)?In my knowledge it is more effective than enzalutamide to block androgen receptors( pcancer cells).

[Poollover in reply to petrig]

After the docetaxel I'll look into it, thanks

[petrig in reply to Poollover]

Nubeqa should start when(same time) in docetaxel.

[Poollover in reply to petrig]

My O only wants me on chemo to help my kidneys.