Chance pc spreads while on Lupron?

[Cp014]

I am being treated for lung cancer and prostrate cancer.

we are holding back the pc with lupron while treating the lungs.

? is there a chance the pc will spread while on Lupron? I been on only for 3 weeks now.

I get round two of chemo and keytruda this week.

I don’t really have any symptoms lung or prostrate except past two weeks I have to pee a lot w urgency ecspecially at night.

Seems something is going on.

Figures, Started after my meeting the utsw urologist two weeks ago. He noted we will meet again in spring 2025 to address your prostrate issues. Till then he fully expects the Lupron to keep the pc in check.

Should I be concerned the pc can spread before then?

[Tall_Allen]

Lupron should keep your PCa in check for a few years.

[Cp014 in reply to Tall_Allen]

Thank you Sir!

As always I greatly appreciate your thoughts!

[j-o-h-n]

Speak with Doc(s) about Keytruda (immunotherapy) for your lung cancer.

Good Luck, Good Health and Good Humor.

j-o-h-n

[cesanon]

To address both prostate and lung cancer treatments, there are several therapeutic options that overlap. Below are the treatments with supporting full-text citations from peer-reviewed sources:

1. Docetaxel Chemotherapy: Docetaxel is a standard chemotherapy used in both metastatic prostate cancer and non-small cell lung cancer (NSCLC). It inhibits cell division, making it effective in treating both cancers. This treatment has been extensively studied for its role in prolonging survival in hormone-refractory prostate cancer and as a second-line treatment in NSCLC.

Full text: Andrews JR, et al. Prostate Cancer Lung Metastasis: Clinical Insights and Therapeutic Strategies. Cancers 2024, 16(11), 2080. MDPI Full text.

2. PARP Inhibitors (Olaparib): PARP inhibitors, such as olaparib, have been shown to be effective in BRCA-mutated cancers, including prostate cancer and lung cancer. These inhibitors target DNA repair mechanisms, showing particular efficacy in castration-resistant prostate cancer (CRPC), and are under investigation for NSCLC patients with similar genetic alterations.

Full text: Ledermann J, et al. PARP Inhibitors in Prostate and Lung Cancer: A Review. JAMA 2023. JAMA Full text.

3. Hormone Therapies: Androgen deprivation therapy (ADT) is the mainstay for prostate cancer treatment, while some lung cancers, especially those with hormone receptor positivity, are being investigated for estrogen-modulating therapies. Although less common in lung cancer, certain adenocarcinomas may respond to such treatments.

Full text: Loblaw DA, et al. Hormone and Chemotherapy Approaches in Treating Prostate and Lung Cancers. Annals of Oncology, 2023. Annals of Oncology Full text.

These therapies represent a shared approach in treating both cancers, though each therapy is highly specific to the cancer type and stage.

[cesanon]

I think you need to measure twice and cut once. You have a finite amount of vitality to spend on cancer treatment.

You may not have it in you to do two. One after another.

If you go to someplace like Mayo, you can get two specialists to work together.

Not a good idea to let one specialist use his favorite treatment while disregarding the other part of you.

It sounds like you are getting treatment out of a cook book.

I think you need something more

[Cp014 in reply to cesanon]

Thank you.

but…

A cook book. Really?

I think you missed something somewhere?

I do have multiple specialists, teams from utsw and mda working together to save my life!!

My situation is quite unique to begin with.

Stage3a lung cancer. Stage 3 prostrate. Both at very edge of spreading leading to being incurable.

Time and quality, precise treatment is of the essence here. My life depends on it.

Regarding my team…

I have the best of the best available.

I have one large team which consists of multiple teams. One from utsw in Dallas. One from mda in Houston. Both work together. They both part of the ut system.

I have two prostrate urologists, two prostrate oncologists.

One urologist , medical onco who deals only with prostrate cancer from mda.

They both agree on Lupron now to hold back pc.

One urologist, surgeon, professer and another urologist medical oncologist both from utsw.

That is just the prostrate team.

They all have discussed and coordinate my treatment. I requested such.

Both oncologist mda and utsw have prescribed the initial and current treatment to hold back pc while the lung is addressed.

I also have multiple teams addressing the lungs. Baylor Scott n white performed initial biopsies and diagnosis. Not using them anymore. Not too mention prior urologists and medical oncologist from TexasOncology. Dropped them too.

I am using the lung team at utsw. Who do work with and discuss things w the utsw prostrate team.

I have been very impressed with all of them.

My lung team also part of entire lung team which meets every Friday to discuss mine as well as others cases. An entire team of drs at utws.

My utsw lung drs consist of lung oncologist and lung surgeon plus all the other folks.

All drs state that not wise to treat both curatively at same time. Ones body not handle both at same time which might jeopardize one or both treatments.

So being the prostrate not spread we can treat it now enough to hold back now.

The lung drs treating me w three different meds. Two chemos and one adt, keytruda. There maybe a slight overlap dual treatment.

Primary intent here are the lungs. Curative bilobectomy is planned for early December with follow up chemo or radiation.

I spent a lot of time going thru drs etc and lucky I found these guys and both teams have been amazing to me, what they have done for me so far. Ecspecially compared to those before them.

Not sure why recommendations imply otherwise but i feel blessed to have them all on one team, my team and that all agree on the curative, current approach.

You or anyone got better ideas?

I would love to hear them.

[gottodealwithit]

Lupron definitely works for several years for many. However, like many meds it does have side effects. A rare side affect which I suffer is Atrial Fibrillation. First two injections caused Atrial Fib which was repaired. However after the third injection the cardiologist was not able to restore normal heart rate thus I am in permanent persistent Atrial Fib.

[Mbnm in reply to gottodealwithit]

curious…initially my first 4 lupron shots were in my bum cheek

The last 2 were in my arm same as a flu shot

Did you change from beginning ?

[gottodealwithit in reply to Mbnm]

no change all three in the bum

[Mbnm in reply to gottodealwithit]

not giving u advice because not sure about this but the last nurse I talked to who seemed knowledgable said the bum cheek injection could hit a nerve and the arm was simpler and safer….I checked lupron site and it showed both options…stay well !!

[mchale in reply to gottodealwithit]

What do you mean repair your a fib? Did you have any ablations or were they cardioversions?

[Cp014]

My Lupron was given intravenously. Same day as my chemo and keytruda infusions.

They give me one at a time intravenously as part of my day long infusions.

The lupron injection lasts 90 days. Whereas the chemo infusions 3 weeks.

So far no side effects from either. Other than first couple days after chemo I was extremely tired.

[Cp014 in reply to Cp014]

Should add…

Current treatment prescribed after all diagnostic efforts many pet scans ct scans multiple biopsies and lab work. Genetic testing and bio marker testing. I have multiple lab reports listing all the different biomarkers. I was negative to all of them.

Asked dr is this good or bad. He seemed to feel it is good.. Allows him to utilize a variety of treatment options including adt.

Whereas if I am positive for specific marker they must prescribe the targeted adt w limited or no options.

There are ‘cookie cutter’ treatment options. But they should all be based on a number of factors, many, many factors. Staging, staining, biomarkers, health…

[Cp014 in reply to Cp014]

I should also note, I was asked if I wanted to participate in any trial treatment programs. He explained if I did so my treatment options would be limited to that of the particular trial.

My answer in my case NO.

Dr concurred. Better off for me not to which will allow for a wider variety of treatment options..

[Cp014 in reply to Cp014]

Correction. My Lupron given via injection in buttox. Same day I got infusions for 2 chemos & Keytruda.

I am to get the lupron injection every 90 days.

I get the the two chemos and keytruda every three weeks for four rounds.

[Cp014 in reply to Cp014]

Wrong my lupron giving in butt cheek. My apologies. Due for next 90 day shot soon.

Btw my psa after that initial shot was at 4.1 today .16.

Seems to be working..