ADT Holiday Unexpected Consequences

[6357axbz]

After stopping Lupron and then, 5 months later abiraterone/dexamethasone, I began to experience what I believe to be arthritis joint pains. Not only in my hips (previously diagnosed with degenerative osteoarthritis) but other joints as well. I did a two week taper-off from the dex but I believe, and so does my doc, that the dex had been masking my arthritis pain, as corticosteroids will do. I have felt no hip pain over the last few years. Now I feel like a creaky old land crap when I climb out of bed in the morning.

Just mentioned this as a heads up to anyone going on “holiday” from ADT.

[Seasid]

oh well holiday

i also started to feel like you recently without going to the drug holiday.

Actually i stopped crestor and I was wondering if I feel like that as a result of stopping crestor.

i didn't use dexamethason can you consider trying crestor maybe it helps you with the inflammation? Make sure that they are no compatibility issues with other medications what you currently use and crestor.

[6357axbz in reply to Seasid]

Thanks, coincidentally my cardiologist just switched me from 80mg atorvastatin, which I’ve been on for years, to 40mg Crestor (rosuvastatin) for better LDL control.

[Seasid in reply to 6357axbz]

i believe all statins have antiinflammatory effects. Yes I was using 40mg crestor daily. Maybe i should go back.

i stopped as I thought that a little cholesterol could be good for my body after years on statins.

the only problem is that I also feel like you and I was wondering why.

[6357axbz in reply to Seasid]

we’ll neither the max dose of atorvastatin or crestor help with the arthritis pain cause I’ve never stopped using one or the other. Only felt the pain after stopping dexamethasone

[Seasid in reply to 6357axbz]

i will try to go back to statins, maybe it helps my aim was just a drug holiday. Hoped to be without statins during the summer in Australia.

[lokibear0803 in reply to Seasid]

May I ask why? What is it about statins that makes you want the summer break?

I ask b/c I’m strongly considering starting statins pretty soon…

[Seasid in reply to lokibear0803]

i hope that I will produce more vitamin d from the cholesterol in my skin after exposure to the midday sunshine.

and i wish to have a break so my PSA can go up a little bit. Crestor could artificially push the PSA down.

but i will go back to statins art some point of time

[lokibear0803 in reply to Seasid]

Sorry if this is a duh question, but why do want your PSA to go up?

[Seasid in reply to lokibear0803]

becaus i want a prescription for Nubeqa

[CSHobie]

I have a side question for you, why were you taking Dex with Zytiga instead of Prednisone? I am on Zytiga and Prednisone, but I am curious as to the benefit of Dex?

[6357axbz in reply to CSHobie]

use this sites search routine to learn about dexamethasone

[6357axbz]

Yes, many of us started on Zytiga/prednisone. On this site I was aware that many had switched to dex. I forget the reasoning but I remembered it was a good argument so when my highly respected MO recommended the switch to dex I was onboard.

[London441]

do you have any joint replacements? How much do you exercise and what kind?

[6357axbz in reply to London441]

no joint replacements

Was lap swimming a couple miles/week but our condo pool has been closed due to Ian

[London441 in reply to 6357axbz]

if you are on drug holiday ostensibly for ‘the benefit of my body would get from having testosterone’, that benefit is minimized unless exercising, especially weight lifting.

More importantly, as someone with both arthritis and high CV risk, I hope your condo pool being closed isn’t stopping you from walking or some other substitute.

[6357axbz in reply to London441]

I have a beagle so walk quite a bit, at least a mile/day.

Why are weights so important? My bone density is about normal for my age and I see no benefit from excess muscle mass

[London441 in reply to 6357axbz]

Older people lose muscle mass continuously, and the older you get the faster you’re losing it. Lifting is the best intervention, and it’s very important unless you just want to accept that process, in which case I wish you luck.

For nearly everyone our age, lifting weights isn’t creating ‘excess muscle mass’. It’s slowing the loss of it, and it’s immensely worth it.

Strength is a prime determinant of longevity, but to be old and strong creates a quality of life unattainable otherwise.

[EchoII]

I wonder if the same is true of prednisone. I am on a holiday from ADT and Zytiga plus prednisone. Noticing some new pains, but mostly muscle pain.

[SteveTheJ]

Who told you an ADT vacation was a good idea?

[6357axbz]

going for labs next week. T was still very low in august. What’s SHBG?

[6357axbz]

my MO suggested it thinking if I could go 6 months, a year, two years with out my cancer progressing the benefit my body would get from having testosterone and not having the cardio risk (I’m a high risk cardio patient) might be beneficial

[tsim]

Yep, steroids will do that. That's why everyone likes them so much.

[6357axbz]

why would I want to do that?

[6357axbz]

thanks

[6357axbz]

my mo will put me on orgovyx when I resume ADT. Last holiday my T was back up after about 60 to 90 days.

[Seasid]

thanks