I have been on Lupron for 8 years with the short-term exception of a high/T clinical trial,( but even during the trial I stayed on Lupron). Anyway I’m undetectable and decided to stop Lupron.
3 months after not getting my shot my T is now a whopping 37.
I am curious to hear from some of you who have stopped Lupron after being on it long-term. I am curious as to any ‘side effects’. I’m experiencing some issues- but I don’t want to influence your comments.
Let me know.
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Chugach
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According to the data, your T-recovery may be very long..many years at least.
Have you considered doing T supplementation? Many papers by A. Morgentaler at Harvard Medical School report that this is a safe and effective treatment for men in your situation.
Some side effects of Low-T are not visible, such as osteoporosis / osteopenia, lipid changes, blood pressure, cholesterol, glucose changes, to name a few. Have you checked all of these lately?
Been on Lupron for over 3.5 years. Have skipped the last 3 month shot and am monitoring while on BAT. After 3 months very low T levels were in place. My MO said it could take several months to witness recovery. If I notice my T not going down during the low T phase of BAT, I shall administer Orogovyx daily.
Here's a plot showing the average % T-recovery versus time for different durations of ADT. For an ADT duration = 3.5 years, the average time for men to recover 50% of their baseline testosterone is 70+ months...not "several months".
That's good that you're doing BAT therapy. Keep us posted on your progress.
I paused Lupron after about 4 years (6 months so far). No side effects from stopping; my testosterone went from 7 to 67 and I feel mildly better in terms of the fatigue. Nothing dramatic but I'm grateful.
I stopped it after 2 so not sure that falls into your definition. All I daw was the reversal of the side effects and nothing I could cj sider a new side effect. I hope you find what your looking for. Glad your doing so well that your able to stop.
After a year and a half on lupron my PSA continued to be undetectable. I decided that if at 2 years it was still undetectable, I would take an ADT vacation. In preparation for the vacation I switched to orgovyx because testosterone recovery is quicker from orgaovyx than lupron.
Once I was off ADT, testosterone rose to 100 within 2 months. Then to 180 at 3 months. (200 is the minimum normal)
From what I understand, had I continued on lupron my testosterone might not have risen significantly for 6 months or longer.
I have no idea of what 8 years of lupron might do to potential testosterone production.
The only other tidbit of information I have is that I did ask my MO if after 2 years of ADT would my testicles even be able to go back into production. He said yes, so that's what I'm working with 🤷
On Lupron for about 2.5 years. I have been off Lupron for about 4.75 years. Since then T recovery high water mark was 97 about 2 years ago and on March 12, 2024 T was 75.
Thanks for your reply Bob. Unfortunately I did not have T tested prior to my diagnosis in December 2016. God willing I will be 75 years old in August 2024. I have been too timid to supplement my T to date. I plan to discuss the subject with my MSK MO this October.
Here's a plot showing the average % T-recovery versus time for different durations of ADT. For an ADT duration = 3.5 years, the average time for men to recover 50% of their baseline testosterone is 70+ months...not "several months". I have no idea about T-recovery when the ADT duration is so long...8 years.
Have you considering doing T supplementation? It's been reported as a safe and effective treatment in your situation (see papers by A. Morgentaler at Harvard Medical School).
Here's a graph of data showing how long it takes for men (on average) to recover 50% of their baseline T. For an ADT duration of 29 months, it should take about 50 months to recover 50% of your baseline.
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