Chemo reduction in PSA

[JolleySprings]

My husband: After 7 years of treatments, we are now to chemo: Docetaxel.

After 2nd infusion PSA went from 47 to 32.

Is this a Good, normal, average, AWESOME 🙏🏻 response?

He has the CDK12 mutation. 😩

Thanks for any comments!

[God_Loves_Me]

Yes it is good response. It will slowly decline and even after completing treatment chemo dosage. PSA will continue decline

[God_Loves_Me in reply to God_Loves_Me]

Does your husband take Nubeqa or xtandi ?

[JolleySprings in reply to God_Loves_Me]

He has taken Nubeqa and PSA continued to climb. However, he is still having monthly Lupron injections in conjunction with the Chemo.

[God_Loves_Me in reply to JolleySprings]

I think doctor should do triplet therapy like Nubeqa, Lupron + Chemo.

[dk73]

that is a good response. My hubby’s PSA rose to 235 after 4 rounds of pluvicto. Now on Jevtana chemo. His last PSA was 59, labs are due this week before round 6. He had chemo twice before (2018 and 2022). They ordered a years worth of Jevtana this time😬

[God_Loves_Me in reply to dk73]

What kind of chemo in 2018 and 2022 ?

[dk73 in reply to God_Loves_Me]

Taxotere, 6x first and 9x in 2022

[macdunno]

yes, he got a positive response from the chemo. However, as your MO would probably continue on this treatment for a while, chemotherapy is harsh on his body and destroys his good cells and cancer cells.

You should monitor his side effects as a result of chemo.