HSP & Prostate Cancer

[Cooolone]

So, I've come across this a few times in my readings. Especially in association with AHCC and PCa. So I'm interested in thoughts on HSP27 and PCa, especially as it seems more prevalent in metastatic characteristics of PCa and castrate resistance (AR).

Welcome thoughts...

[Tall_Allen]

Several HSP inhibitors (against HSP27 and HSP90) have been tried. They have minimal activity and high toxicity.

[j-o-h-n]

To Cooolone,

I'm considered dope by my family and I knew what HSP27 is but I think maybe some of our members don't, so:

Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in different disease states playing both protective and counter-protective roles. The current review presents HSP27 in multiple disease contexts: renal injury and fibrosis, cancer, neuro-degenerative and cardiovascular disease, highlighting its role as a potential biomarker and therapeutic target.

p.s. Just love those acronyms, they were responsible for my military DD 214.

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 04/10/2021 12:51 PM DST

[MateoBeach in reply to j-o-h-n]

Thank you for providing that context. And for your service! 👍🏼

[j-o-h-n in reply to MateoBeach]

Thank you for the thank you...But in those days we didn't have any choice unless we wanted to be Canucks........

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 04/11/2021 2:02 PM DST

[Hidden in reply to j-o-h-n]

😂

[GeorgeGlass in reply to j-o-h-n]

Even the top brass at the Pentagon went apeshit when my fellow action officers gave them exec summaries with numerous unidentified acronyms lol

[j-o-h-n in reply to GeorgeGlass]

I forgot you were an officer.

This one would really get their attention: "PUSSY" (Preserve United State Soldiers Youthfulness"....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 06/09/2022 5:36 PM DST

[GeorgeGlass in reply to j-o-h-n]

lol. Yes, Milley and Austin would have sore asses after reading that.

[Hidden in reply to j-o-h-n]

😂👏🏼👏🏼

[Hidden in reply to j-o-h-n]

❤️👏🏼👏🏼👏🏼

[Cooolone]

Thanks for all the replies! Now I'm really confused?!?!O.o

Lol

[Hidden in reply to Cooolone]

Welcome to the club! 😂✌️