PSA back up after radiation

[alperk]

After 4 .5 weeks of radiation PSA dropped from 6.6 to 3.46 but on 6/3 went up to 5.88. I have MO appt 6/11 and he has previously indicated that docetaxel could be the next step. Following last PSA increase switched from Zytiga to Xtandi. I am guessing that a PET scan is in order and maybe SBRT prior to docetaxel. What do you guys think?

[Tall_Allen]

The combination of docetaxel and Xtandi has been shown to keep it working longer.

prostatecancer.news/2022/10...

[NecessarilySo]

I realize you already most likely know this but I needed to know what sclerotic lesions are so I'm posting this fyi. I suspect some of your sclerotic lesions are pc metastases. They seem to be growing in spite of your Lupron, hence, they are castrate resistant.

"Benign sclerotic lesions often do not cause symptoms and may be discovered incidentally during imaging tests for other conditions. However, if they are large or located in certain areas, they might cause pain, stiffness, swelling, or a lump near the affected area. The pain can worsen at night or after activities that put weight on the bone1.

Malignant sclerotic lesions are less common and usually result from cancer spreading from other parts of the body to the bone. They can cause similar symptoms to benign lesions but may also lead to nerve compression, which can cause numbness or tingling sensations. Lesions in the neck might affect swallowing or breathing1.

The causes of sclerotic lesions vary. Benign lesions can be due to conditions like blood vessel inflammation, collagen vascular disease, sickle cell disease, Gaucher’s disease, alcohol abuse, long-term corticosteroid therapy, embolism, or ongoing bone infections like osteomyelitis1. Malignant lesions often originate from cancers such as breast cancer, kidney cancer, lung cancer, lymphoma, multiple myeloma, prostate cancer, or thyroid cancer1.

Diagnosis typically involves a combination of personal and family medical history review and imaging tests like X-rays or MRIs to examine the bones more closely1. Treatment depends on whether the lesion is benign or malignant and may range from monitoring to surgery or other therapies2."

healthline.com/health/scler...

webmd.com/a-to-z-guides/wha...

[Mgtd in reply to NecessarilySo]

That was informative. Thanks.

[j-o-h-n]

You beat me in years of fighting the beast, but I beat you in age.

Back in the old days the use of Cryotherapy was almost unheard of. But apparently you did and it worked. Three cheers for you!!!

Good Luck, Good Health and Good Humor.

j-o-h-n