Possible Good News: CHROMOGRANIN A, EIA Normal range: 0 - 187 ng/mL Mine is lower than ever 86ng

[Shorehousejam]

CHROMOGRANIN A, EIA

Normal range: 0 - 187 ng/mL

Date Value Normal Range

May 2, 2024

86ng/mL

0 - 187 ng/mL

Oct 10, 2023

97ng/mL

0 - 103 ng/mL

Sep 7, 2023

117ng/mLHigh

0 - 103 ng/mL

Just got home from Liver Biopsy, so far No Complications, Thank God

[Ahk1]

I wish I can find an answer to exactly what this cgA indicates for sure. And What does it means. Mine is always on the high value.

[Shorehousejam]

Chromogranin A (CgA) is a protein released by neuroendocrine cells. Neuroendocrine cells are found in many organs in the body and have characteristics of both nerve cells and cells that make hormones.

A test for chromogranin A measures the amount of CgA in the blood. This is known as a tumor marker test because CgA can be released in higher than normal levels in patients with tumors of the neuroendocrine system.

There is no consensus among experts about the optimal use of CgA testing for people with neuroendocrine tumors (NETs). Chromogranin A may be measured to help evaluate the effectiveness of treatment for NETs. CgA levels may also be considered when assessing prognosis, and, less often, they may be a part of the diagnostic process for NETs.

[Shorehousejam in reply to Shorehousejam]

Ugh, this may not be good….

Chromogranin A potentially false-negative results

Chromogranin A concentration may be normal in the case of neuroendocrine tumors with a mild proliferative potential. These include the majority of neuroendocrine tumors of the appendix, which apart from a few cases are mostly benign tumors, which when totally excised do not require a follow-up after treatment. About 75% of insulinoma tumors are usually mild and CgA is usually not increased, but in this case the measurement of CgA may be a helpful indicator of tumor malignancy. Besides several typical lung carcinoids, duodenum and rectum low proliferative index tumors may not show elevation of circulating CgA [11]. Rapidly proliferating, poorly differentiated neuroendocrine tumors, which in many cases lose their characteristic structure and show a much smaller number of secretory vesicles, may also not release the marker, giving false negative results.

Although CgA is not a specific marker for particular neuroendocrine tumors, one of its derivatives, neuroendocrine secretory protein 55 (NESP 55), seems to be a specific marker of pheochromocytoma and pancreatic neuroendocrine tumors, neuroendocrine tumors which are not present in the gut [53]. However, so far this marker can be used only with immunohistochemical techniques, and it is impossible to use it as a circulating marker.

[Tall_Allen]

Not sure why this interests you?

[Shorehousejam in reply to Tall_Allen]

Because of the liver lesions found as Chromogranin A is a tumor marker for Neuroendocrine and Small Cell Carcinoma, my 3 test are above, the last test, last week seems to be at my lowest

[Tall_Allen in reply to Shorehousejam]

Serum Chromogranin A is not a tumor marker for Small Cell, only tumor Chromogranin A is.

[Shorehousejam in reply to Tall_Allen]

Do you mean Chromogranin A is a marker for Neuroendocrine but Not for the worst of it, which is Small Cell Carcinoma,

That doesn’t sound good, it seems I’m worst off than before

[MoonRocket in reply to Shorehousejam]

I think he's saying you need to test the tumor and not what's in the blood. At this point just wait for the biopsy for conclusive results rather the emotional rollercoaster of what the blood tests results mean.

[Tall_Allen in reply to Shorehousejam]

No. Serum vs Tumor.

[Shorehousejam in reply to Tall_Allen]

Ok, I’m reeling from anxiety with my wife on this mess…

Still hopeful and praying

[j-o-h-n]

I must admit it's confusing..... But keep your chin up....(don't forget the boss)...

Good Luck, Good Health and Good.

j-o-h-n

[Shorehousejam in reply to j-o-h-n]

Thank you