pubmed.ncbi.nlm.nih.gov/339...
This is from 2021. Does anyone know if any progress has been made in the use of Sarms for Prostate Cancer. My son who has PC sent it to me.
The following link is what I found:
usada.org/spirit-of-sport/e...
Thank you very much.
Drug makers abandoned after cancer showed up in mice at 60X dose. I have been on them for 2+ years now. Started when ADT began to fail, gave me another year. I still am taking as it facilitates muscle growth.
Thanks so much for the reply. I will let my son know. Right now he’s struggling from ADT weight gain despite exercising and changing his diet.
I talked to my son and he’s going to ask his oncologist next time he goes in for treatment. Does your oncologist approve of you taking it? I will talk to my son after he visits his doctor and post what his oncologist has recommended. I know my son is interested because of the weight gain but I’m not convinced it’s the best way to go, but I tend to go with scientific studies and there aren’t any NIH studies or elsewhere that give it the OK to take.
Gaining muscle is a slippery slope, you need lots of calories to build muscle, then cut calories to lose excess fat. Not Easy with ADT. I have had success with intermittent fasting. 12, 24 and then 36 hr fasts. My MO knew exactly what it was and how it works and while he couldnt recommend it because not FDA approved if I where his son he would have me take it. Interested to see what another Oncologist thinks of this
Thanks for the information. Even following a vegan diet and hiking every day he hasn’t been able to lose weight so it is definitely a slippery slope . He hasn’t tried fasting yet, but I will mention that to him..Thank you for the information from your MO …we’ll see what my son’s has to say. I just read on your profile that you’re working with a personal trainer too, and I will mention that to him also.
Hi! As ex personal trainer I can tell you that hiking is (to put it in a simplistic way) too aerobic to avoid muscle depletion. And (again simplifying a lot) the main difference between aerobic and anaerobic training from an energy point of view is that aerobics make you burn more than weightlifting while you are doing it…but weightlifting (=muscle mass) makes you burn calories even while sleeping. Simply because muscle needs calories just “to exist” even when you don’t use it.
How are you doing? And how is he doing? 😊😊
I took a break over the holidays to try to slow down my motherly worries. He is doing well except that he has gained weight . I talked to him about doing weights but he doesn’t enjoy weights and he loves hiking and he’s talking about adding biking to the hiking ….will biking help? He’s going to buy a mountain bike. How are you doing too?
I understand. People who love outdoors seldom like gym. I have the same problem with aerobic activities, I like running/cycling, but not on a stationary bike or a treadmill! For bones health you need impact load, the best is jumping (even jumping the rope) as it can load your bones with 2-3 times your body weight, then running, then weightlifting. Walking and cycling do not have that effect of repeated load-unload. For muscle mass he could try creating a HIIT routine with his bike. Short bursts of 30 secs-1 minute at the maximum speed he can achieve, then 2 minutes of unload, at an easier pace. Rinse and repeat at least 20-30 times. He could do the same with bodyweight exercises like push ups, short bursts at full speed then rest (actually more than rest he should switch to a different exercise). But there is no way around anaerobic activities when you need muscle mass. He should "sacrifice" and see it as medicine, it does not take long, 30 minutes 5-6 times per week is enough if done properly, then he can hike 
I am doing like usual, a rollercoaster of emotions, a treatment that is working fine but a genetic mutation that could make it lose efficacy sooner than normal...looking into both research a non standard treatments as long as they are at least proven not to hurt my situation and have some confirmation at least in vivo (better if clinical)...it's all a matter of probability, so we are in God's hands. I will have my last chemo on wednesday, then I can only hope that the cancer will be "frozen" long enough for some better treatment. I am lucky I had almost no side effects, which allowed me to still keep the situation hidden to my mother. Trying to find out how to live what is left of my life without knowing if I am talking 2 years or 30 years, which is a challenge itself! Usual life of a terminally ill! 😜😜
Thank you for all the tips and information. I told him about your personal training background. I hope he uses the information but am not sure that he will.He loves the outdoors so much.
Yes PC is a roller coaster of emotions. My son and I took a day trip over Christmas and talked about the past year. What a year! He feels the same way as he doesn’t know if it’ll be a couple of years or 30 years but while we were driving we were almost hit sideways by a truck going about 80 miles an hour jumping a red light…both of us would’ve been instantly killed… so we both decided that we could die today just walking across the street or from something else so the end of the line isn’t necessarily going to be PC …that brush with death scared both of us but it helped put life into perspective. It’s just that PC hangs over all our heads like a gloomy cloud and it’s hard to escape. I just hope that they find a way soon to control it like you mentioned …..you know like HIV! I think you handled the chemo really well and that’s not easy .🙏🏻🤭to you and all of us going into 2024. We need it! So happy we all have each other to support one another.
Your son needs to start loving resistance training. These meds won't work their magic without resistance training. Personally I'd stay away from SARMs. The risk is not worth the reward. A gym membership and a training plain is all that is needed. Of course a tight diet is essential to loose weight. It can be done but it's not fun.
Thanks.I agree with you. He’s watched his diet but hasn’t added resistance training yet. I guess he really needs to. I am against SARMs too and hope he won’t take them.
I ended up being prediabetic from the ADT and hormone imbalance. GP put me on Ozempic and dropped 20lbs while getting my numbers down
Any stomach issues with Ozempic?
Not a single one. If you insist on over eating carbs u will get sick
Wow! What an experience …it’s amazing how powerful these drugs are but I’m happy that it turned out well for you. So far, I think my son‘s numbers have been OK but it’s really a month-to-month thing. he’s been off his vegan diet so I hope this time when he goes in everything will be OK.
some more
link.springer.com/article/1...
Extract from Wikipedia references: “Unfortunately, results of recent clinical trials of the SARM GTx-024 (Enobosarm) have tempered expectations for its utility as a therapy for muscle wasting. Early on, GTx-024 appeared to have a very bright future as a treatment for sarcopenia/cachexia. Preliminary clinical trials demonstrated that GTx-024 could increase lean body mass and improve physical function without androgenic side effects (27). However, Enobosarm was dealt a blow after the phase III Prevention and treatment Of muscle Wasting in patients with cancER (POWER) I and II trials, where increases in lean body mass were once again observed, but without improved stair climb power (79,80). Failure to attain both primary endpoints led to a lack of approval by the Food and Drug Administration (FDA), which has cast doubt on the previously charted course for SARMs and has tempered enthusiasm regarding the role of SARMs in the treatment of muscle wasting conditions.”
I do not remember if your son is metastatic to his bones but if he is I would be worried by the fact that, as they say, only AR in muscles and bones are activated.
They are used for breast cancer and enlarged prostate from what I understand, but not for prostate cancer and I am afraid it has something to do with metastasis.
But I will find more info.
Thanks so much for the new information. The last PSMA pet scan showed no Mets in the bones and he is still taking the Lupron and generic Zytiga and prednisone. I just sent your information right onto him and will be anxious to learn more. Thanks again!
PS although there were no bone mets, he was treated for tertiary 5 Mets in the pelvic lymph nodes. He received five or six weeks of I MRT radiation for that and his numbers have been low since March 2022. He had his surgery on October 24, 2022 and two months later instead of his PSA going down it went up to 22 and from a PSMA Pet Scan we discovered that the PC had spread to some pelvic lymph nodes and that led to ADT prednisone and generic Zytiga and radiation.
Tertiary 5 is an aggressive form of PC. Since the radiation they have not found any spread to the bones but it’s still quite early. That’s why I’d like to see him stay away from SARMs just to be on the safe side, although it could spread either way.It’s such a sneaky disease.
Maybe in his case benefits of sarm could outweigh risks then. I am not even touching creatine because I know it can help when you are a stage 1, but can help the spread of bone metastasis when you have them. It's all in vivo/vitro for now, but there should be the results of a clinical trial soon! At least I will know what to do.
Thanks. I would like to see him stay away from SARMs and add the resistance training! But it’s his decision. He’s going to talk to his MO and I am afraid she will say it’s up to him and not tell him the downsides but unfortunately there isn’t anything I can do. And when he goes to see the MO hopefully all the test will prove OK again on his ADT.
I don’t think I would want to take it either if I were you, I guess I like to err on the side of caution.
Been dealing with this for 7+ years, feel like I have been lucky and made the right moves for me
It sounds like it’s worked for you…so happy for you that it has! My son is high risk Tertiary 5 so any unknown scares me . I guess he will have to go with his intuition. Hopefully if he does, he will have the same good luck as you and I hope he starts doing weights!
I have found that the longer I live with this the less I care about new treatments, holistic treatments and micro-managing my disease. I have accepted my death and have made financial moves to keep my wife a well to do widow. If I go tomorrow so be it, if I live 20 more years good for me. I have mentally freed myself from the trappings of this world. Living life to the fullest every single day
Hi! One of the guys Scout4answers (look for him) posted his new year update. Years of Lupron with almost non detectable PSA, in his opinion the "almost" is because at a certain moment he played with SARM - RAD140...
I found his answer a little bit difficult to understand, but I think that’s what he’s saying too that he stopped SARMS because his PSA went up. My son hiked yesterday and also started weight training. He said he was in bed before 8 PM.! Totally worn out!
Custom BAT program
Update after 6 months on SARMS Osterine and Carderine along with ADT
Podcast Re Immunotherapies for PC
