Researchers from WEHI and Trento University (Italy) have answered an age-old question: which function helps mutant p53 fuel tumour growth?

[Maxone73]

The study revealed that the loss of function in the mutated p53 protein is the critical factor in cancer growth, disproving the previously suggested gain-of-function role. Using CRISPR gene editing, the researchers removed various mutated forms of p53 and found no change in cancer cell behavior or response to chemotherapy.

Restoring p53's normal functions reduced cancer growth in pre-clinical models. This discovery could redirect the focus of cancer treatment research away from targeting gain-of-function traits to restoring the protein's normal tumor-suppressing functions, potentially saving millions in drug development costs.

wehi.edu.au/news/cracking-t...

[MateoBeach]

Good to know that fully functioning p53 is an effective cancer fighter.

Always reminds me of the P51 Mustang fighter/bomber from WWII.

[Maxone73 in reply to MateoBeach]

I hope we can use it to bomb the bastard….

[j-o-h-n in reply to MateoBeach]

Rat-tat-tat-tat-----------rat-tat-tat-tat--------rat-tat-tat-tat------- 11 o'clock high 11 o'clock high LOOK OUT JOE-----rat-tat-tat-tat.....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 12/03/2023 6:23 PM EST