A biological “switch” which can cause cancer cells to self-destruct.

[anonymoose2]

BREAKING: Researchers at UC Davis Comprehensive Cancer Center have discovered a biological “switch” which can cause cancer cells to self-destruct.

The research team was able to identify and activate a crucial epitope that signals a swift death of cancer cells.

Cancer cells have cell membranes that contain protein receptors known as CD95 receptors. These receptors are designed to destroy the cancer cell. Once they are activated, they will release a signal that causes the cell to self-destruct. The trick to killing the cancer cells off is found in a crucial epitope (or a segment of a larger protein) on the CD95 receptor. The UC Davis research team, led by senior author Jogender Tushir-Singh, said their discovery is the first to successfully target the kill “switch.”

“We have found the most critical epitope for cytotoxic Fas signaling, as well as CAR T-cell bystander anti-tumor function,” according to Mr. Tushir-Singh.

nature.com/articles/s41418-...

[GrantB47]

This sure sounds like a big deal to me.

[anonymoose2 in reply to GrantB47]

I thought so

[TwilightZone]

This sounds like the best thing I've learned since 2015, when first diagnosed with prostate cancer!

[Cactus297]

I opened the study and it appears to be on ovarian cancer not prostate. So would it be applicable to prostate cancer?

[Maxone73 in reply to Cactus297]

The title is misleading. In the article they talk about ovarian but also about solid tumors in general. Problem is, it’s still in vitro. But the more potential tools the better

[anonymoose2 in reply to Maxone73]

Any and I mean any advancement is a positive to me. Hope is a good. Biden when he was running for office his stump speech he mentioned he was going to be the president who would find the cure for cancer. Probably BS, but I still hold that as hope also. I’m not giving any endorsement just remember him saying that so don’t shoot the messenger please.

[Maxone73 in reply to anonymoose2]

I agree with you 100% !!!

[Cactus297 in reply to Maxone73]

So it’s not close to becoming a reality? Just a beginning stage?

[Maxone73 in reply to Cactus297]

Correct. But research is gaining speed also from an initial idea to a phase 1 clinical trial.

[Cactus297 in reply to Maxone73]

Thanks. That sounds great. My son has Stage IV and was diagnosed just before his 50th birthday so he’s young like you. Congratulations on your wedding!

[Maxone73 in reply to Cactus297]

Thank you! Unfortunately the only person I cannot tell about my condition is my mother. She is 94 and made of steel (completely independent)…but if she knew her youngest son had a terminal disease, I am afraid she would go insane. Thank god I have not yet lost my hair with chemo!

[Cactus297 in reply to Maxone73]

I know how your Mom would feel. I am glad that my son told me, but it has been tough ever since. He’s doing well on ADT with his numbers but let’s face it it’s really hard on his body. Knowing what he’s going through, I have to try to be stronger than I thought I could ever be, but I am 78 and your Mom is 94. Yes I agree. I’m glad you haven’t lost your hair! My son has always told me that I’ve been his rock but it’s best that he does not how fragile this rock can be!🤫

[Maxone73 in reply to Cactus297]

La mamma è sempre la mamma we say…and you are always rocks, and always worried! I wish you and your son all the best. I am posting a lot about new research and so on…we are not so far from making it a chronic disease. Curing a stage 4 is another story, but if we can manage it as we did with HIV it would be more than enough to live without fear! Stay tuned!

[Cactus297 in reply to Maxone73]

You are so right “Mom is always mom!” ☺️…. I would be so happy if it could become a chronic disease just like HIV where as you said, one can live with it …that’s all that is necessary ……putting it in its place so patients can successfully live with it. I hadn’t thought of it that way before…. But it’s a wonderful and hopefully attainable goal. I wish you and your Mom the best too. My maternal grandmother lived to be 100 after raising 12 children! I will watch for your posts.

[Cactus297 in reply to Maxone73]

That’s great to hear …it can’t be fast enough for all of us!

[j-o-h-n]

Do they say if the switch works if it's used on ex-wives?

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 11/19/2023 5:09 PM EST

[anonymoose2 in reply to j-o-h-n]

I would think so. They are known to contain protein. Who’s ? I haven’t a clue.