(Don't stop reading because you don't have diabetes!)
New Israeli study below.
Once again we find that:
"... diabetes posed an increased risk of cancers of the liver, pancreas, gallbladder, endometrium, stomach, kidney, brain (benign), brain (malignant), colon/rectum, lung (all, adenocarcinoma, and squamous cell carcinoma), ovary, and bladder, as well as leukemia, multiple myeloma, non-Hodgkin lymphoma"
"Diabetes was associated with a reduced risk of prostate cancer."
Everytime I read this result in a new study, I wonder why this hasn't been translated into useful information.
The transition to the diabetic state involves three states:
- insulin resistance, with increased beta cell insulin production
- atrophy of the beta cells
- inability to produce sufficient insulin
Giovannucci reported that protection against PCa took about a year to kick in after the diagnosis of diabetes.
Two things come to mind (others might have additional ideas):
[a] Insulin is a PCa growth factor. A reduction in insulin production might slow the development of PCa. For non-diabetics, restoring insulin sensitivity might be protective. The metabolic syndrom is common in PCa.
The first line of treatment after diagnosis is Metformin. Perhaps Metformin is the reason for reduced risk?
{[c] or both of the above}
But we already have PCa.
Dr. Myers seems to have finally embraced Metformin in his practice.
It seems prudent, regardless of our situation, to restore insulin sensitivity & consider using Metformin.
-Patrick
[1] ncbi.nlm.nih.gov/pubmed/272...
